ID I3IWI2_ORENI Unreviewed; 2554 AA.
AC I3IWI2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ATR {ECO:0000313|Ensembl:ENSONIP00000000972.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000972.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000000972.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR STRING; 8128.ENSONIP00000000972; -.
DR Ensembl; ENSONIT00000000971.2; ENSONIP00000000972.2; ENSONIG00000000770.2.
DR eggNOG; KOG0890; Eukaryota.
DR GeneTree; ENSGT00940000155714; -.
DR HOGENOM; CLU_000178_2_1_1; -.
DR InParanoid; I3IWI2; -.
DR OMA; SMYIGWC; -.
DR TreeFam; TF101183; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1607..2153
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2261..2554
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 2554 AA; 286246 MW; F003CFDD8D498788 CRC64;
MEGLEMSAMI PALQELASAS AAEYDQVVQK PRQILCQFID RILTDVDVVA LGLNKKSSSE
PACVMLLDFV QHIVKSSSLM FANPACQPAE YPDTTQSCTD FSKWVAVRFL RVAAAPGCDI
IHGRVSAVLC SLLHTLRVRA PFIFNCLIQE LIFLCQELSH NLYAHICTLG GQGHVLEIHT
KSQWPVNLKC FSLSPLCASS YLTPSALVLS SPAALESLTA ITIDIITESL RGVISRRDLS
LAWEAACFIL ANGNTRLRKA SMVMLRTLVE LRGFPEMQGH EFFAAYFQLL ETHSCSATAN
INEKEAYEGE LLSLTRCVFQ PSYVSHSHFE PIYLSQMFEC VCTLAGAGVK LGVEVTESLC
LLFSFSLSVA PVYESAALLR RQRVTEVCGT LACTVGTANQ AECAEGFLRA ALKAETALVL
QECNDGATPV KKSCKSATSS VGKTPKTSSS EVDMRVRSKV WAALSSRLEE LLMLLDSSSA
KPETTQSLSA LQGLALILHQ AALCSSPVSS LSPLLWVPTE TLSRALKSCQ SVLEGGSQPV
SNRSYFQSAV QITVRVLDSI LYLTMSSQND DRLQQHVCAL LSLSWVCENK SVSAYKTSGF
PSWLLALAQK LSFCYSPEVQ ADCVSLLAFL HGGVCETWRV CVFSKALQSQ EEVVRVAAVK
AFPLLLHHLG NMHYNLIGTT LLSKLEDSSE QVKKELARII GQLSCLQSEL SSLNNIHTDS
TGLPKILCLS CSLEADHAGK AVPSLRASVV RPFLPLLRPQ APSTVKQAFL EALPHLCQHV
NLTGADSDSR AILYALIGLM EDSDPVVRTC FSQSVRFLVT ETTRNSEQGS LNELLVARLK
EAFSNAKLNR DDDLRNTLIL TTGEIGRASQ GSLVSFSLLR LLHCLLSKSS QVSVAAYTQI
RALATTKGLK LQTLFSQYKN PICQFLVESL HSRHASALRS TPDQGTESAN QRELALDILA
QIAHAFDFPD LHRFLTRTLQ VLLPYLAAKA SSTGSALIRT LAIELKANRR EILINNFKYI
FSHLVCSCTK EELERAFHYL QSETEIELGS LLRQDFQGLH NELLLRLGEH YQQVFNGLAI
LASFASSDDP YQGPRDITTP ELMADYLQPK LLGILAFFNM QLLSSSAGEK DRKKLVLTSV
MALMRLMGSK HISSVRVKMM TTLRTGLRYR EDFPLLCCQT WDCFVRSVEP AHLGPLLSHV
IVALLPLIPL QPKETAAIIR FLILDNREEV SDYLHEIYFL PDHPELKDIH AVMQDYKKLA
ASSSDLAAAL QLSMRAVQHE NVDVRIHALT SLRDMMHSNQ EWLLRQVCAS EAVEPVISNL
VSVLLKGCQD SSPEARLLCG ECLGELGAVD PGRLDLSQTH THGNRNTFVS GVDDPNFAYD
LLTELTRTFL AYADDVRAQD SAAYAIQELL SIFECREGRT DSAGRRLWRR LPEQIQEILE
PHLNSRYKSS QKEVNWSKLK KPVYLSSRGS KFSDWSATWA GYLISKVRHE LASKVFRCCS
FIIKHDYKVT IYLLPHILLY MLLGCTPAEQ QEVTEEMLAV LTEGDGQAEG LAQKTASSLS
QLSTQTVFSM LSHLTQWSRH ILYSKPKHES GDYQRVVAFL KDIPQDVLAK ASLRSKAYTR
ALMHFEAYIL ENKENVQDHL TFLQTLYAAM HEPDGVRGVN ALRREEPSLQ EQILEHESIG
LLRDATACYD RAIQLESDQI AHYHGVMTSM LGLGQLSTVI TQVNGVLANK HQWKSELNTY
RVEAAWKLGK WDLLEDYLSS DQQSSTWGVR LGQLLLSAKK QDAEKFYEKL KLVRKEQVVP
LSAASYECGT YQRGYEYIVR LHMLSELEHT FNELLKQRQG SVSNLSQLPP HWSDRLEMTQ
NSFRAKEPVL ALRRALLSLG TQPECQELVG ECWLQSARVA RKAGHHQTAF NALLNAENTN
LAELVTEKAK WLWSKGDVHQ ALIVLQKGVA QCFPEDQPLT DPRSLQTKGK AMLLVGRFME
ETANFESNAI MKTYKDVTNL LPEWEDGNFY LAKYYDKVMP MVTDNKLEKQ GNLIRYIVTF
FGNALQFGNQ YIYQAMPRML SLWLDFGAKV CECEKAGRAD RQMRQELSKI NTVMSEHCSK
LAPYQFLTAF SQLISRVCHS SDEVFNVLMT IVAKVFLTYP QQAMWLMTAV SKSSYPMRMN
RCNQILKKAV SLKQSLEKFI GDANRLTDKL LELCNKPVDG NSTTLSMSIH FKQLKRLVEE
PTFSQILIPL QSVLIPTLPS TGGENTQHDA FPGHWAYLDG FEDSVEILAS LQKPKKISLK
GSDGRSYTMM CKPKDDLRKD CRLMEFNCLI NKCLRKDAES RRRELHIRTY AVIPLNEECG
IIEWVNNTAG LRHILTKLYK ERGIYLSGKE LRKLILPKTA PFEEKLRIHK EVLCARHPPV
FYEWFLRTFP DPTSWYSSRS AYCRSTAVMS MVGYILGLGD RHGENILFDS FTGECVHVDF
NCLFNKGETF DVPEVVPFRL TRNMVHAMGP MGIEGLFRQA CEVTIRLMRD QREPLMSVLK
TFLHDPLVEW SKQGKGLSKA QANETGEIVN EKVG
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