ID I3IYQ0_ORENI Unreviewed; 769 AA.
AC I3IYQ0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=DNA helicase MCM8 {ECO:0000256|ARBA:ARBA00041084};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN Name=MCM8 {ECO:0000313|Ensembl:ENSONIP00000001740.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001740.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001740.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR AlphaFoldDB; I3IYQ0; -.
DR Ensembl; ENSONIT00000001739.2; ENSONIP00000001740.2; ENSONIG00000001379.2.
DR GeneTree; ENSGT01090000260080; -.
DR HOGENOM; CLU_000995_7_2_1; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 350..540
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 769 AA; 84633 MW; DCCC4005E95AD4C1 CRC64;
MNSCNKITNC STVSSVLCQT TLDALCPYKG WTLYFTDESG PNVEKIKVFE KYFTFRIHLF
DKDEIERQGS VLVDYADLIA DKTVRHALPD IVTQLKQQPE VMLNCLGLAI HQVLTLDLQK
QAAELQEEEF PVATPVINIP HISARLYNYE PLTPLRMLRA SVFGRLVCVK GTVVRVSSIR
PLCTRLAFRC RTCSTTLSLA LQHGKYTTPT KCGKPDCRSH TFIPIRNSPL TQTVDWQIIK
VQELISGEQR ETGRIPRTVE CHLTSDLCDS CVPGDTVTVT GIVRVSNDGT KTHILIIVKS
SSGTVEDRCG GEEFSLKELY AIQEIQSQPD LLLKSCGSCN SCVFLSLQLV KAALALVLFG
GRQKQTGKNS IPVRADPHIL IVGDPGLGKS QMLQLRLLCN VAPRGIYVCG NSTSTTGLTV
SLSRDAGTGD YALEAGALVL ADQGLCCIDE FDKMGNQQQA LLEAMEQQSV SLAKAGIVSS
LPARTSVVAA ANPVGGHYNR GKTVSENLKM GSALLSRFDV VFLLLDIPDE SHDRQLSEHV
MANRSGRGRT SSATVTRNNS ELQTSILLEH SDMPLSERLQ VPAGETIDPI PTCLIRKYIS
YARQYVHPKL SPEAAQTLQE FYLSLRAQAN PTDATPITTR QLESLIRLTE ARAKLELRET
ATKSDAEDVV EIMKHSLANT YSDGLGNLDF ERSQLGSGMS QRSAAKRLVN ALHQHAQRTG
QKQFDVQTLR SIADRVNVKV MDFEGLLSSL NEQGFLLKKG PKLYQLQTI
//
