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Database: UniProt
Entry: I3J0B9_ORENI
LinkDB: I3J0B9_ORENI
Original site: I3J0B9_ORENI 
ID   I3J0B9_ORENI            Unreviewed;      2150 AA.
AC   I3J0B9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002309, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000002309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000002309}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000002309}.
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DR   EMBL; AERX01012501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01012502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01012503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000002309; -.
DR   Ensembl; ENSONIT00000002310; ENSONIP00000002309; ENSONIG00000001850.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; I3J0B9; -.
DR   OMA; AVKRSSW; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    126    143       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    263    284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    348    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    381    403       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    546    564       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    584    608       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    673    692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    751    775       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    924    942       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    954    977       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    997   1020       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1041   1074       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1124   1145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1166   1192       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1235   1260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1272   1296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1429   1447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1521   1544       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1678   1712       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      784    807       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2150 AA;  241082 MW;  33D100A6977EFDF0 CRC64;
     NTHLHQLHPS QSLHPPASTG KPVGSAHGLL GANNSIQGPG GAAPGVSPVL AWHAAISAAR
     QAQVCTTSAP APVGSLAQKK RQQYAKSKKQ GGSTSGRPPR ALFCLTLNNP IRRACISLVE
     WKPFDIFILL SIFANCVALA IYIPFPGDDS NSTNQELETV EYAFLIIFTI ETFLKIIAYG
     LVMHQNSYVR NGWNMLDFVI VIVGLFSVVL EMITKDADSG GQSGGKPGGF DVKALRAFRV
     LRPLRLVSGV PSLQVVLNSI IKAMVPLLHI ALLVLFVIII YAIIGLELFI GKMHATCYVT
     ETAPGALAEE EPAPCAISGH GRHCLLNGTV CREGWQGPNN GITNFDNFLF AMLTVFQCIT
     MEGWTDVLYW MNDAMGFELP WVYFVSLVIF GSFFVLNLVL GVLSGEFSKE REKAKARGDF
     QKLREKQQLE EDLKGYLDWI TQAEDIDPEN EEEGDEEGKR NRELPGYLTE KKKGKFGWFT
     QSTETQASIP TSETESVTTD NHNGEEDKSP CCGPLCQKIT KSKCSRQWRR WNRFCRRKCR
     AAVKSVTFYW LVIILVFLNT LTISSEHYNQ PDWLTEVQDV ANKVLLALFT LEMLVKMYSL
     GLQAYFVSLF NRFDCFVVCG GIVETILVEL AIMSPLGISV LRCVRLLRIF KVTRHWASLS
     NLVASLLNSM KSIASLLLLL FLFIIIFSLL GMQLFGGKFN FDETVTKRST FDNFPQALLT
     VFQILTGEDW NTVMYDGIMA YGGPASSGMV VCIYFIILFI CGNYILLNVF LAIAVDNLAD
     AESLNTAQKE EEEAKKRKNS ARDASADKKR CDIAESKDGE TKVKIQRFTL YSQTADIHIT
     LKVPLEGLQE ENKELYPSSD SPVCDDGTDN DELPEVPSGP RPQRLSELTI KEKIPPIPEG
     SAFFIFSSTN PFRVFCHKLI NHQIFTNLIL VFIMLSSVSL AAEDPIRNFS ARNIILGYAD
     YVFTSMFTFE IFIKMTAFGA FLHKGAFCRN YFNLLDLLVV GVSLVSFGIQ SSAISVVKIL
     RVLRVLRPLR AINRAKGLKH VVQCVFVAIR TIGNIMIVTT LLQFMFACIG VQLFKGKFYR
     CTDDAKSSPD ECKGTYILYN NGDTALPMVK ERIWYNSEFN FDNVLMAMMA LFTVSTFEGW
     PTLLYKAIDS NRENMGPIYN YRIEISIFFI IYIIIIAFFM MNIFVGFVIV TFQEQGEKEY
     KNCELDKNQR QCVEYALKAR PLRRYIPKNP YQYKFWYVVN STGFEYVMFV LIILNTLCLA
     IQHHGQSHLF NYAMDILNMV FTGVFTVEMI LKLIAFKPRN YFADAWNTFD ALIVVGSVVD
     IAITEINVGS HSCCQGDSGA RVKCTVKFPV CASPPGVVHI CISVLENVVP FIPLSHNNSF
     PHPLQNTEDS ARISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIAML
     FFIYAVIGMQ VFGKIAMVDG TQINRNNNFQ TFPQAVLMLF RCATGEAWQE IMLACMPGKL
     CDPESDYNPG EERTCGSGFA IIYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH
     HLDEFKRIWS EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVAMNMPLNS
     DGTVMFNATL FALVRTALKI KTEGNLEQAN EELRAVIKKI WKRTSMKLLD QVVPPAGDDE
     VTVGKFYATF LIQDYFRKFK RRKEQGLVGR RSWERLNTTL ALQAGLRTLH DIGPEIRRAI
     SCDLQEEGLV DENAEEEEEI YRRNGSLFGN HVNHIGGDQQ ASSHPTTVTQ RPLQILPFSS
     AASTEPPQIV RRASSNDSST CVQSPIPSNA NLNNANVPSL LSMTIARQQK CLRRSRPSST
     RNASSTTTYS KGLQGKPWKS HSTRSDCHKT CKDGKCANKL YVYVTVSYSI RCVTISEYCS
     SNDIMLTKSE SYCDDDQRPI YQDSRPSPRK WFLPSPQASN RPTFSFECLR RRSSEDDAPP
     SPSCTALPLH LMQQQVMAVA GLDASKIHRL SPTRSMRSWA TPPASPVSRD FSPSYTPLIQ
     VSLVDWRSPG SVASIPGAVK RSSWYTDSQD GPPSQSHSPS RLHLPAECCS HCLQKRGSAN
     SLVEAVLISE GLGKYARDPK FVSATKHEIA DACEMTIDEM ESAASNLLNG
//
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