ID I3J0M6_ORENI Unreviewed; 1978 AA.
AC I3J0M6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit a {ECO:0000313|Ensembl:ENSONIP00000002416.2};
GN Name=CACNA1E {ECO:0000313|Ensembl:ENSONIP00000002416.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002416.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000002416.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 8128.ENSONIP00000028603; -.
DR Ensembl; ENSONIT00000002417.2; ENSONIP00000002416.2; ENSONIG00000001928.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000155601; -.
DR HOGENOM; CLU_000540_1_0_1; -.
DR TreeFam; TF312805; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF5; VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 86..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 934..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 999..1021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1111..1136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1192..1211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1223..1245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1257..1281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1407..1431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1568..1602
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1654..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1730..1899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1744..1796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1797..1859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 303
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 635
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1082
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1978 AA; 224715 MW; 2B460D9C0696D409 CRC64;
MARFGDDVPG LLSSGDGGSE RIRNRDGAAV STGGISPAFK QTKAQRARTM ALYNPIPVRE
NCFTVNRSLF IFGEDNVVRK YPSTPFEYMI LATIIANCIV LALEQHLPGE DKTPMSKRLE
KTEPYFIGMF CFEAGIKIIA LGFVFHKGSY LRNGWNVMDF IVVLSGILAA AGAHMNISVD
LRTLRAVRVL RPLKLVSGIP SLQIVLKSIM KAMVPLLQIG LLLFFAILMF AIIGLEFYSG
KLHYSCIPKP GILGTDVEFP CGVRKCPAKY TCNDTWIGPN DGITQFDNIL FAVLTVFQCI
TMEGWTTVLY NTDDALGPRW NWLYFIPLII IGSFFVLNLV LGVLSGEFAK ERERVENRRA
FMKLRRQQQI ERELNGYRAW IDRAEEVMLA EENKNPGPSA LDGKSTGIFF VSLSPPKGIP
MTRTSIRSTK RGPTAYFRRK ERLLRISIRR VVKTQTFYWT VLGLVALNTL CVAIVHHNQP
LWLSNFLYYA EFLFLALFLT EMLLKMYSLG PRLYFHSSFN CFDCSVIVGS IFEVLWGFFR
PGTSFGISVL RALRLLRIFK ITKYWASLRN LVVSLMNSMK SIISLIFLLF LFIVVFALLG
MQLFGGRFIF EDYTPTNFDT FPAAIMTVFQ ILTGEDWNEV MYNGIRSQGG VKSGMWSSVY
FIVLTLFGNY TLLNVFLAIA VDNLANAQEL TKDEEEAEAA FNQKHALQKA KEVGPLSSFM
SSERERGKRM TMSVWEQRTS QLRRHRQMSS REILFSSPTE EKDGPPASSQ AHVRPLSLHR
KAMQTPSGSI KHLTDPLASP AKTQPSGSSI SVDVPLDDPE QCKSEKEESE ETKPANSVIP
DSMFIFKPDN PVRRACHYVV NLRYFEMSIL LVIAASSIAL AAEDPVATSS HWNKVLRYFD
YVFTGVFTFE MIIKMIDQGL ILHDGSYFRD LWNMLDFVVV VGALVAFALT NVMGNNKGRD
IKTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM FIFAVIAVQL
FKGKFFYCTD SSKDTEKDCQ GYYIDYGKDK KEVKRREWKR HEFHYDNVIW ALLTLFTVST
GEGWPQVLQH SVDVTEEDRG PSHGNRMEMS IFYVIYFVVF PFFFVNIFVA LIIITFQEQG
DKMMEECSLE KNERACIDFA ISAKPLTRYM PQNRHTFQYR LWHFVVSPSF EYTVLAMIAL
NTIVLMMKYY SAPPAYEAVL KHLNTAFTVL FSVECILKIL AFGFLNYFRD TWNIFDFITV
LGSITEIVVD LQFVDTINMS FLKLFRAARL IKLLRQGYTI RILLWTFVQS FKALPYVCLL
IAMLFFIYAI IGMQVFGNIK LNEETHINQH NNFKSFSGAL MLLFRSATGE SWQEIMLSCL
AGQKCETDPL LQADSTDPEG GCGSDFAYFY FVSFIFFSSF LMLNLFVAVI MDNFEYLTRD
SSILGPHHLD EFVRIWGEYD RAACGRIHYT DMYEMLTNMS PPLGLGKKCP SKVAYKRLVL
MNMPVDDDMT VHFTSTLMAL IRTALEVKIA RGGEDRNQMD LDLQKEISVI WPHLSQKTLD
LLVPIHKASD MTIGKIYAAM MIMDYYKQSK AKKLRQQLEE QKHAPMFQRM DASSLPQEIL
CNAKSLSFLR HSAGSALTRG GFVALSPISP QEMFLQPLSR PREEKEEDDE DDYHSPYHPY
QSICVLVGVI PGYLNNASSD SKLMKRSFST IGDQCVNGLW QEQHSLERIS PDATYRPRQR
SYRGPRINHK ETISHERGRS KERRHLLSPD VSRCNSEERS RDPSCERRRS RSPSEGRTHT
LQKQVNTSDS PAHSTSESGT PRNRRQLPQT PSRPRPYISY SPLVSSNEGQ SQPQDTPAGP
TEASLGVDKE SRPLSAVQGS SGVHVSGPSH PSPHRYISEP YLPFHEDLSS GEASERQDTL
TFETAVATSL GRANAISSAP QLRHSWQVPN GHFRKHLGQT SPAGASELLS DTDEDDRC
//
