ID   I3J0Y6_ORENI            Unreviewed;       497 AA.
AC   I3J0Y6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Family with sequence similarity 126 member A {ECO:0000313|Ensembl:ENSONIP00000002526.2};
GN   Name=fam126a {ECO:0000313|Ensembl:ENSONIP00000002526.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002526.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000002526.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the Hyccin family.
CC       {ECO:0000256|ARBA:ARBA00034482}.
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DR   AlphaFoldDB; I3J0Y6; -.
DR   STRING; 8128.ENSONIP00000002525; -.
DR   Ensembl; ENSONIT00000002527.2; ENSONIP00000002526.2; ENSONIG00000002018.2.
DR   GeneTree; ENSGT00390000011295; -.
DR   HOGENOM; CLU_027457_3_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG22.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018619; Hyccin.
DR   PANTHER; PTHR31220:SF4; HYCCIN; 1.
DR   PANTHER; PTHR31220; HYCCIN RELATED; 1.
DR   Pfam; PF09790; Hyccin; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   REGION          380..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   497 AA;  54184 MW;  BC5EB30EE4D1B516 CRC64;
     MLAMDQGVVE EWLSEFKTLP DSAVSTYAAS LKDKGALVPA LYKVIRENYS DLLEPVCHQL
     FEFYRSGEPQ LQRFTLQFLP ELLWSLLSVS AARDPHTSGC IEALLLGIYN LEIVDKDGQS
     KVLSFTVPSL SKPSVYHEPS TIGSMALTEG ALANHGLSRV VYSGPHLQRE TFTAQNRFEV
     LTFLLLCYNA ALSYMSSTSL QSLCQLSSRV CICGYPRQQM RRYKGINTRL TVTSEFLVQL
     ITGIHYALCN GEVDLGSKAL DDVLYRAQLE LFPEALLVGN AIKSSLHSAA LKSNNKEGAR
     SIQVEITPTS SRISRNAVTS LSIRGHRWKR HEFLHLMDIS EVDEGVWPGG AGPDMTPPTI
     TISNSVTTLN LGAKAMKKCR LGGRTSKDKD KEAGPLMPGR AASENTELSV KRLTLTSSQS
     VPKAGALTSL TRTASAVFSR SFEHVASGNA PPSSNHTTSE AGRYSCSLQE EGLAYLSPAP
     NHTQRSPSIS VHLGSDL
//