ID I3J2Y3_ORENI Unreviewed; 800 AA.
AC I3J2Y3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Chromatin assembly factor 1, subunit A (p150) {ECO:0000313|Ensembl:ENSONIP00000003223.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003223.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003223.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CHAF1A family.
CC {ECO:0000256|ARBA:ARBA00006913}.
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DR AlphaFoldDB; I3J2Y3; -.
DR STRING; 8128.ENSONIP00000003223; -.
DR Ensembl; ENSONIT00000003224.2; ENSONIP00000003223.2; ENSONIG00000002573.2.
DR eggNOG; KOG4364; Eukaryota.
DR GeneTree; ENSGT00440000034888; -.
DR InParanoid; I3J2Y3; -.
DR OMA; DPWAQDK; -.
DR TreeFam; TF350377; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR InterPro; IPR029105; CAF1-p150_C2.
DR InterPro; IPR029091; CAF1_p150_N.
DR InterPro; IPR022043; CAF1A.
DR PANTHER; PTHR15272:SF0; CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A; 1.
DR PANTHER; PTHR15272; CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A; 1.
DR Pfam; PF11600; CAF-1_p150; 2.
DR Pfam; PF15539; CAF1-p150_C2; 1.
DR Pfam; PF15557; CAF1-p150_N; 1.
DR Pfam; PF12253; CAF1A; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 8..149
FT /note="Chromatin assembly factor 1 subunit p150 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15557"
FT DOMAIN 547..773
FT /note="Chromatin assembly factor 1 subunit p150 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF15539"
FT REGION 25..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..189
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..513
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 90999 MW; 3329355BEBE94D02 CRC64;
CVCFHFSGMD CKSSNNASKK LVQARLPFKR LNPEPKENQP PKRPCAHSCP EPEVSDRENE
NASSPLSVRS GPPLVNGRGP LDGFISRRRA ATSDENMIID LTEDNTSSPL KPLASSASTS
PCVSAKDKHH CKDTTASPEK SCSANDAPKT QTLDCVVINN DDKEEEEKEE EEEEEEEEEE
EEEEEEEKEE KNNTASISQL DTTQDSDTEA EELNESENVS SLGNRLQEQD ERLRLRQEKE
RQKEEAKAAK EKKKEEARKL KEEREREKRE KKEKDEREKR EKKEKEEREK AERLKTVMCS
VSCSTFKMNH LTVLFWLQRL KAEKAEITRF LQKPKIQQAP KTLAAACGKF APFEIKENMA
LAPLCRVQCE ESALEELDRC LLNPADNRNG LKDWIGQKPR QSGPTKPRQT NSLRDCITVE
GPKPDSVPDR KRYGPMKLLQ FHENYRPAYW GTWSKKSSHI SPRCPFRQDK GLLDYEVDSD
EEWEEEEPGE SLSHSEGEDE EEGGEDDDDD DDGFFVPHGY LSEDEGALEE EDGGDLEKQK
LRQKLKAREW DELMSSKKKM KVLEPVVRGC IWEGEAPGIE LLQSYAVCLV EPLPKADNIL
GKLLPLLHGN LNSSKVIINE FREFCRQETT SSSPPVLSSP QNPAENIPSR MQLRRLIKNN
AVYEKRSAHR RCCWYVHHEA LSRFGQEALP VPCQWTYLTT GAATGSQGNS PTTPQSCSTT
PSSSNKRKST GSMSITKFMK RCNDPEQTEA MEADGFQADT EDDDEDDCVI ISTQSGKLHR
KIIIIFFKLY LLTVIFNFKV
//
