ID I3J4I4_ORENI Unreviewed; 1501 AA.
AC I3J4I4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 {ECO:0000313|Ensembl:ENSONIP00000003774.2};
GN Name=PLEKHH2 {ECO:0000313|Ensembl:ENSONIP00000003774.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003774.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003774.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSONIT00000003775.2; ENSONIP00000003774.2; ENSONIG00000003014.2.
DR eggNOG; KOG0248; Eukaryota.
DR GeneTree; ENSGT00940000157675; -.
DR HOGENOM; CLU_001626_3_1_1; -.
DR InParanoid; I3J4I4; -.
DR OMA; WCILIGK; -.
DR TreeFam; TF312866; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 709..804
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 818..926
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 962..1117
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1128..1459
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 196..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 50..77
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 103..137
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 212..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..426
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1501 AA; 166841 MW; 9A60245FE73D38EB CRC64;
ETQAFYPTSQ TLSLSLLPGE EAMSQEDWKE KCVVLEALLM KFRVQIIKIR ELTADKIQQL
ETQVIDAEKR AFTAQQQMQW MEEKLKAADG QSGDSEVRLF QRCQELQALV QEKEDVIAQL
EQQLEEQKQL RLQDAKTVEE KAAKIKEWVM LKLSEVNLSF EQKCKGGAGA LCRPGEAQRL
SSLTFGCFQV RGKNPQVLTG PAPSQKTLST QGETDARDKT GKSPHSHTAM DNENSICEWL
DGTPGSKKTA SSVTDGEGHK PSQTGLLCSP LEDDGAPESS VSNACGPESR RVLSVLSSAA
SVEEELCESR SGACGLEISR PSSETYLTAS DDSSSLFDDD MQRTERPSFS LLESSDGTLA
GCKNEEEEGR TAKLEDCTSE ELNKRFQSQR LDSSSSSSEP NTPSPILTPA LTPKRPNPPQ
DPKDNPASPK QPRLRTPTGF GLMNVSLAKK HLSQPSISSE AAHGQTRNAL SMLRPLQPQE
TDVDAQQEVG METGKAIVPE ILPGSQAATT VPSAPNSSEP GTEMGSERPD CDSTTPGSKP
PTPPLHRLPS WESRIYAVAK SGIRLSDTSC TGLSNKDPSL QSSYPAFVMY TSLIYKNMTT
PVYTTLKGKA TLLSSSPFSD ESSSSEESSS SGDEDGSLCS SHTSSSSRKD SSPGSPRSLK
RAVSVASMTS ECDYAIPPDA YSTDTECSEP EQKLPKTCCS SSDNGKSEPM EKSGYLLKMV
KTWKKTWKRR WFVLKDGELL YYKSPSDVIR KPQGQIKISA TSSIARGDGK QVLQIVTGKR
VYYLKADSPN LLEEWLRVLQ SVLRLKAASP LFTQPDIRPG MKGLLIKVKH GYSKRVWCAL
IGKTLYYFRS QEDKFPLGQI KLWEARVEEV DRSRDSDDDL KACGRGLQPA PFTIAIHPQE
QGPTYLLIES CHEKESWLYH LSVAAGTTVG KVGTEFEQLV GKLFQLDGDP NSQIWRHPML
CFSKEALSFP LTTLPSQALQ TEAVKLFKTC QLFINVAIDA PAIDYHVSLA QSALQVCLAH
PELQNEFFCQ LIKQTRKRQP HSHPGPLQGW QFLALCVGLF LPQHPFLWLL QIHLKRHADA
RTEVGKYTIY CQRSMERTQQ KGERQARPSR MEILSILLRN PYHHSLPFSV PVHFLNNTYQ
VVSFDASTTV DEFQCRLNQD TGMRKTGLSG FSLYTDDPTG RSLEHCLQGG LKICDIISKW
EQASKEHHTG KSENTRTVRL TYKNRLYFSL QVRGESERER LLLAYQTNEA IVAGHFPVNK
ELALEMAALL AQVEFGDFER PFSTSGSAQT KSNQNLKQVL DRFYPKHYRR STSEEQLRQL
LQRLSARWAS LRGRSSPECI RIYLTVARKW PFFGARLFEA ESITPSPEPG VRVWLAVHED
GISVLEHNSI KLLVCYSYKN LMTFGGCKQD FMLVMGQNVG TNASKDKPTE KHLFAMDPSK
IREVTLLISS YINSAHQQKA AAHHLSAPAL MVAQPVRLKS KELRSKSPPA LGRPSKAPTL
L
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