ID I3J5A1_ORENI Unreviewed; 1130 AA.
AC I3J5A1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=EMILIN-1 {ECO:0000313|Ensembl:ENSONIP00000004041.2};
GN Name=LOC100707680 {ECO:0000313|Ensembl:ENSONIP00000004041.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004041.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004041.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_013119709.1; XM_013264255.1.
DR AlphaFoldDB; I3J5A1; -.
DR Ensembl; ENSONIT00000004042.2; ENSONIP00000004041.2; ENSONIG00000003220.2.
DR GeneID; 100707680; -.
DR eggNOG; ENOG502RIZH; Eukaryota.
DR GeneTree; ENSGT01030000234633; -.
DR HOGENOM; CLU_319805_0_0_1; -.
DR OrthoDB; 5314586at2759; -.
DR TreeFam; TF331033; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF1; EMILIN-1; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF07546; EMI; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1130
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025404922"
FT DOMAIN 45..122
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 985..1130
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 129..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 310..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 794..832
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 390..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..970
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 122871 MW; A59A4DB76B5C84B9 CRC64;
MAALPLLLLL VLWTCGHAKG AFPLRQSYNL YTNGHAHGAR AASRHRNWCA FVVTKTVSCV
VEDGVETYVK PDYHPCSWGS GQCSRVVVYR TYMRPRYKVA YKMVTEMDWK CCHGYSGADC
NIGPAGGVGT QISTTRPQPG QGGGTTSGQG GGGHSYGGGS SGSGQSGGNA DNEKMRQLEE
KIRSLTKNLQ DLQSTMSTMN ERLQEEGGRN GLGGGSSGGR NPADAAQPEI KETIHSIQTK
LDQLDNRTQA HDKTLVSINN HLVNGKGNEL EGGVSGGSLS EGRLNSLKEE ILSELERRVS
LSCSSCQAGV EDLRKQQQQD RERIRALEKQ MNAMDAQYRQ SLDGLRQEVV RSQGCCDIIS
DLQDRVTDAE RKISTASENF DILQNRMDRE LSGQGGTSSS ENTGSETGGH GRDAVVTEER
LNNRLKDLER RVNSTMQKTE ESCSYLENDV KDYFHRELDE LRSVFLERFD DQADRIADVE
LDVERVKASI SDHDKRLSKL ENTTSQMNWR LEKCGCVASE QGGGGDGGYG GGTWGAGGGG
GGGSTGGGGR WGGTGGGLPG TGGERDNSTK KSLEWRVVAN EDQIRHFNTR LKDLSMSGDS
LYGKVLDLTH DVGKIKALTG DHGEHFNRIV TVVEMLGEDC ELCRKVEEEL QKMKNYSQNA
LSNIQNHIDR IQNRLDSEGD SCFQICSDLQ SEVSVLRDDV RRCTNQCKSN PDMTTGVDHA
RPGGTDDNSG QLDPAKPLDG HSVIEGINNN HLKTLQGELS NVILTFSSIN DTLKGLEHTV
QKHDSVITDL GNTKDKIISE IDKVQQELTE HMQDNRDRLD KMERDIRRFE STVLEMGDCK
RSGDGLEKRL SKLEGVCGRL DGVSDSILKI KEGLNKHVSS LWTCVSGLND TVIRHGGLLD
FIQNGQDDIH SRVKNLNSSL NQVSRDLQSL SEHDLTGPPG PQGPPGERGF NGLPGLPGPP
GFPGPQGEIG PPGPKGETGL PGADSQIPKL SFSAALTAPM DRAGTIVFDK VFVNEGNFYN
PRTGIFTAPI DGNYYFSAVL TGHRNEKIEA VLSKSNYGMA RVDSGGYQPE GLENNPVAEA
KVNPGSLAVF SIILPLQTQD TVCIDLVMGK LAHSVEPLTI FNGMLLYEDK
//
