ID I3J5X3_ORENI Unreviewed; 531 AA.
AC I3J5X3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Potassium voltage-gated channel subfamily G member 4 {ECO:0000313|Ensembl:ENSONIP00000004263.1};
GN Name=LOC100690615 {ECO:0000313|Ensembl:ENSONIP00000004263.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004263.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004263.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_005447870.1; XM_005447813.3.
DR AlphaFoldDB; I3J5X3; -.
DR STRING; 8128.ENSONIP00000004263; -.
DR Ensembl; ENSONIT00000004264.2; ENSONIP00000004263.1; ENSONIG00000003385.2.
DR GeneID; 100690615; -.
DR KEGG; onl:100690615; -.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000156938; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR InParanoid; I3J5X3; -.
DR OMA; VHMERCC; -.
DR OrthoDB; 1478695at2759; -.
DR TreeFam; TF313103; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18382; BTB_POZ_Kv6_KCNG; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF167; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 4; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..169
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 488..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 60466 MW; F9C925E41DE7003A CRC64;
MPIISNANHD FSTYSISSDD SSLDRFFTEI PETETLKGVY FQRAQLLRDP KASYVVDRTL
QVLVNVGGNR YTFPWSTLEQ FPQSRLGRLR FCTTPEEIAR LCDDYDETCQ EFFFDRNPTA
FRVILNFLAA GKLRLLRELC AVSLHDELDY WGVDPGHMER CCRRRMMARV EEVAERERKE
EEWRQKRMML KKTSTQTEKG YRRLIVVLRD MVENPHSGLA GKMFACLSIV MVMVTVISLC
ISTMPDLRDE ETKGECSQKC HNMFVVESIC VAWFTLEFVL RFINAQSKLA FARGPLNIID
AVAILPYYVS LVVDIKDESH EDVIMGAGRG YLDKLSLILR LLRALRILYV MRLARHSLGL
QTLGVTMQRS MREFGLLLLF VCVAVTLFSP LVHLAESELA PFAATHPHHS FSSIPASYWW
AIISMTTVGY GDMVPRSIPG QIVALTSILS GILIMAFPAT SIFHTFSRSY QELKQEYKRV
WKEERDEEIA AESGKSCSKD HSSLDELKSV SKNGNDGMKS SKTPTLPSAA F
//
