ID I3J7Q1_ORENI Unreviewed; 354 AA.
AC I3J7Q1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Protein AMBP {ECO:0000256|ARBA:ARBA00018905};
GN Name=LOC100689743 {ECO:0000313|Ensembl:ENSONIP00000004891.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004891.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004891.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the calycin
CC superfamily. Lipocalin family. {ECO:0000256|ARBA:ARBA00008238}.
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DR RefSeq; XP_005451428.1; XM_005451371.3.
DR AlphaFoldDB; I3J7Q1; -.
DR STRING; 8128.ENSONIP00000004891; -.
DR MEROPS; I02.005; -.
DR Ensembl; ENSONIT00000004894.2; ENSONIP00000004891.1; ENSONIG00000003882.2.
DR GeneID; 100689743; -.
DR KEGG; onl:100689743; -.
DR CTD; 259; -.
DR eggNOG; KOG4295; Eukaryota.
DR GeneTree; ENSGT00940000160109; -.
DR HOGENOM; CLU_067584_0_0_1; -.
DR InParanoid; I3J7Q1; -.
DR OMA; CPWLKRI; -.
DR OrthoDB; 3558236at2759; -.
DR TreeFam; TF351222; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd22596; Kunitz_bikunin_1-like; 1.
DR CDD; cd22597; Kunitz_bikunin_2-like; 1.
DR Gene3D; 2.40.128.20; -; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 2.
DR InterPro; IPR002968; A1-microglobln.
DR InterPro; IPR029856; AMBP.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR PANTHER; PTHR46676; PROTEIN AMBP; 1.
DR PANTHER; PTHR46676:SF1; PROTEIN AMBP; 1.
DR Pfam; PF00014; Kunitz_BPTI; 2.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01215; A1MCGLOBULIN.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00179; LIPOCALIN.
DR SMART; SM00131; KU; 2.
DR SUPFAM; SSF57362; BPTI-like; 2.
DR SUPFAM; SSF50814; Lipocalins; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 2.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..354
FT /note="Protein AMBP"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003672004"
FT DOMAIN 235..285
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 291..341
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 354 AA; 39376 MW; 940B4DBB11913CE1 CRC64;
MQKAATVVTL LVLGWTWNLE GLPVLTDPLY PTQENFDLTQ YLGKWHDIAI ASTCPYMQRY
KSGAAIGKLV LQRGDNEGKL KVTRSSLRRG TCMERIADYE LTTTPGRFFY HVAKWGADVD
AYVVHTNYNE YAIVIMSKQK LSGNKTTSVK LYSRTMTVRN TVLDDFKRLV KDQGMSDANI
IIKQDKGDCV PGEEVATATT HSKPQRVRRN AVPSLAPDVE GSGDDTAMFN GTEACKAAPD
TGPCFGLHQR YYYNSSSMNC ELFKYGGCLG NQNNFESERD CLQSCRTEAV CRLPMDAQPC
TGKPPIWAFD STAGLCVAYK QGFCQANSNK FYSKAECEEY CGVMKDDEGL LKAN
//
