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Database: UniProt
Entry: I3J7R3_ORENI
LinkDB: I3J7R3_ORENI
Original site: I3J7R3_ORENI 
ID   I3J7R3_ORENI            Unreviewed;      5072 AA.
AC   I3J7R3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSONIP00000004903};
GN   Name=LOC100709030 {ECO:0000313|Ensembl:ENSONIP00000004903};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004903, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000004903}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000004903}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000004903}.
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DR   EMBL; AERX01055378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01055379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000004903; -.
DR   PRIDE; I3J7R3; -.
DR   Ensembl; ENSONIT00000004906; ENSONIP00000004903; ENSONIG00000003892.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; I3J7R3; -.
DR   OMA; QNANTDM; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IEA:Ensembl.
DR   GO; GO:0008345; P:larval locomotory behavior; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 7.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4357   4380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4593   4613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4676   4698       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4872   4894       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4953   4976       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      212    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      587    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1342   1555       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1857   1881       {ECO:0000256|SAM:Coils}.
FT   COILED     1927   1949       {ECO:0000256|SAM:Coils}.
FT   COILED     3696   3723       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5072 AA;  574513 MW;  649C87FA4D8CBD2B CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL LYGHAILLRH HHSGMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPISSGCEL AEGYLTGGHV LRLFHGHMDE CLAIATPEEG
     EEKRRMAHYE GGTVCSQARS LWRLEPLRIS WSGSHMKWGQ SFRIRHITTG RYLCLDEEKG
     LLVVDPEKAN TKLSAFCFRA SKEKVDVAQK RDVEGMGIPE IKYGESMCFV QHVSTGLWLT
     YAALDAKAAR LGMMKRKVIL HQEGHMDDAL TVSRSQTEES QAARMIYSTT GLFRQFINGL
     DSLSGKNKSL GTGSLPLESV ILSLQDLIFY FRPPEEELEH EEKQTKLRSL RNRQNLFQEE
     GMITIVLECI DRLNVYNTAA HFSEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFC
     DNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKVLD
     VLRSLCVCNG VAVRSNQNLI TENLLPGRDL LLQTNIVNYV TSVRPNIFLG TCEGSTQYKK
     WYYEVMVDHV EAFVTAQASH LRVGWALTEG YSPYPGGGEG WGGNGVGDDL YSYGFDGLHL
     WSGTVARQVA SPSAHTLAAD DVVSCCLDLS VPSISFRING HPVQGMFENF NVDGLFFPVI
     SFSAGVKARF LLGGRHGDFK FMPPPGYAPC YEALLPRERM RIEHIKEYKH DFDGVRNLLG
     PTLSLTHTSF TPCPVDTIQI VLPPHLERIR EKLAENIHEL WAVTRIEQGW TYGIFRDDNK
     KLHPCLVDFQ SLPEPEKNYN LQMSAETLKT LLALGCHVGM GDEKAEENLK KIKLPKTYVM
     SNGYKPAPLD LNHVKLTPNQ NQLVEKLAEN GHNVWARDRV RQGWTYSIVQ DIVNKRNPRL
     VPYNLLDERT KKTNRDSVNN AVRTLIGYGY NIEPPDQEST GHGLENTRGD KVRIFRAEKS
     YAVTQGKWYF EFEAVTTGEM RVGWARPNVR SDTELGADEL AYVFNGNKAQ RWHIGNEPFG
     RQWQSGDVVG CMIDLTEMNI MFTLNGEMLI SDSGSEMAFK DIEIGDGFIP VCTLGLSQVG
     RINLGQNVSS LRYFAICGLQ EGFEPFAINM KRDITMWFSK SLPQFVPVPA DHNHIEVSRV
     DGTVDSAPCL KLTHKTFGSQ NANTDMMFLR LSMPVQFHET FKIPAGTTPL TRALTIPEEE
     VAVVEPDSEF EVLKKSASRK EQEEDKKDPS VPKEISVENE KDTMSEKGKK KGFFSKAKKA
     AMTPLAPPPA PPTVPRLVED VVPDDRDDPE IIQSTTTYYY SVRIFAGQEP SGVWVGWVTP
     DYHMYDQNFD LSKVRSVTVT VGDDKGNIHD SMKHSNCYMV WGGDLVSNQQ TRFSQEDMVI
     GCLVDLATGL MTFTANGKEI NTFYQVEPNT KLFPAVFVQP FSQNMVQLEL GKLKNIMPIS
     AAMFRSERNN PVPQCPPRLD VQMLTPVIWS RMPNHFLKPE VGKVNERLGW MVECVEPLIM
     MALHIPEENR CIDILELSER QDLMKFHYHT LMLYCAVCAL GNNRVAHALC SHVDESQLFY
     AIENTYLPGP LRSGYYDLLI SIHLESAKRA RLGTNREFIV PMTEETLSIK LYPDAIKAHS
     LPGVGLTTCL RPKLHFSSIN FVGTDPDLYT ISPVFPLQEL KTKAISMLRE AVLDGSQAMR
     DPVGGSVEFH FVPILKLIST LLIMGIFNDD DTKHILKMID PNVFSGKEEE EAEEGGAAEG
     ENEEKKEEES EEAAEDELED EGVGDEEEEE LKELEKPEGE EEEAEPKEEG EEGEKDKEEA
     KRGKVDGEKA EEEKESEAVE AEAQEEEEGL EEGLLQMTLP ESVKLQMCTL LQYFCDCELR
     HRVEAIVAFS DQFVHDIKSN QRVRYNQLMR AFTMSAAETA RKTREFRSPP QDQVLMLTNF
     KHQEDEDSPV PEDVRETLAE FHKDLLLHCG IHIEEEPEEE EVDTSLRGRL LSLVDKVKSL
     RKKKEEEEKP EVEEEPKPST LQELISHTMI HWAQESFVQN PELVRLMFSL LHRQYDGLGE
     LIRALPKAYA INAVSVQDTM ELLECLGQIR SLLIVQMGPE EERLMIQSIG NIMNNKVFYQ
     HPNLMRALGM HETVMEVMVN VLGGGGDSKE IRFPQMVTSC CRFLCYFCRI SRQNQRSMFD
     HLSYLLQNSG IGLGMRGSTP LDVAAASCID NNELALALQE QDLEMVVTYL AGCGLQMCPM
     LLSKGYPDIG WNPCGGERYL DFLRFAVFVN GESVEENATV VVRLLIRRPE CFGPALRGEG
     GNGLLAAMEE AIKISEDPAR DGPTVKKDRR FMFGGEEQHE ENRVHLGNAI MSFYSALIDL
     LGRCAPEMHL IQAGKGEALR IRAILRSLVP IEDLVGVISL PVQIPAYGKD GQIIEPKMSA
     SFVPDHKASM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTVAFS TTEMALALNR
     YLCSAVLPLL TKCAPLFAGT DHRAIMIDSM LHTIYRLSRG RALTKAQRDV IEECLMSLCK
     YLRPSMLQHL LRRLVFDVPI LNEYAKMPLK LLTNHYERCW KYYCLPNGWA NFGVTSEEEL
     HLSRKLFWGI FESLAHKKFD AELFKIAMPC LCAIAGAIPP DYVDASYSSH TEKKASVDAE
     GNFDPKPVET TNTIIPERLD PFVNKYAEHT HDKWAFEKIQ NNWTYGEVLD ENAKTHPMLR
     PYKTFSEKDK EIYRWPIKES IKAMLAWEWT IEKARDGEGE VEKKAAATTT TRKISQTAQA
     TYDPSHGYSP QPIDISGMAL SRELQSMAEQ LAENYHNTWG RKKKLELQSK GGGTHPLLVP
     YDTLTAKEKA RDREKAQDLL KFLQLNGYAV TSPRGLKDME QDISSIEKRF AYGFLQKLLK
     WMDIAQEFIA HLEAVVSSGR VEKSPHEQEI KFFAKILLPL VNQYFKNHCL YFLSTPAKVL
     GSGGHSSNKE KEMIASIFCK LAALVRHRVS LFGTDAPAVV NCLHILSRSL DARTVMKSGP
     EIVKAGLRQF FESAADDIEK MVENLKLGKV SSRNQVKGVA QNINYTTTAL LPVLTSLFDH
     IAQHQFGDDV MLDDLQISCY RLMCSIYSLG TVKTPHVEKQ RPALGECLAH LAAAMPVAFL
     EPVLNEFNSF SVYTTKTPRE RAILGLPNQV EELCPDIPEL EILMKEIHDL AESGARYTEM
     PHVIEITLPM LCNYLPRWWE RGPESFPEQD GQLCTAVTSE QLNQLLGSIM KIVVNNLGID
     EASWMKRLAV FAQPIVSRAK PEMLKSHFIP TMEKLKKRAA KVVAEEDHLR MEGKTEVDSE
     NGTIRDEFAV LCRDLYALYP LLIRYVDNNR ARWLTCPDPD AEELFRMVGE VFIFWSKSHN
     FKREEQNFVV MNEINNMSFL TADSKSKMSK AGDGESGGSE QERTKKKRRG DRYSVQTSLI
     VAALKKMLPI GLNMCSPADQ ELINLAKIRY SLKDTDEEVR EFLHNNLHLQ GKVEDPAMRW
     QMSLYKEMSG KAEDADDPEK VVKRVQEVSA VLYHIEVTEH PFKSKKMVWH KLLSKQRRRA
     VVACFRMTPL YNITTHRVTN MFLDAYKRNW LETEGYSFED KMIDDLSKAM EEEEEEEEET
     ETKPDPLHQL ILHFSRTALT EKLKLDVDHL YMSYADIMAK SCHIGEEDEG GEQEGEEPSF
     EVRQTEMEKE MEKQRLLYQQ SRLHNRGAAE MVLQMISACK GEPGAMVSST LKLGISILNG
     GNSDVQQRML DYLKDKKDVG FFLSVQSLMQ TCSVLDLNAF ERQNKAEGLG MVSEEGTNEK
     VMADDEFTCD LFRFLQLLCE GHNNDFQNYL RTQTGSTTTI NVIICTVDYL LRLQESISDF
     YWYYSGKDII DEPGKRNFSK AMTVAKQVFN SLTEYIQGPC TGNQQSLAHS RLWDAVVGFL
     HVFAHMMMKL AQDSSQIGLL KELLDLQKDM VVMLLSLLEG NVVNGTIARQ MVDMLVESSS
     NVEMILKFFD MFLKLKDIVA SDAFRDYVTD PRGLISKKDF SKAMDSQKQY SPSEIQFLLS
     CSEADENEMI NFEEFADRFQ EPAKDIGFNI AVLLTNLSEH VPHDTRLQNF LEQAESVLNY
     FRPFLGRIEI MGASRKIERI YFEISEENRN QWEMPQVRES KRQFIFDVVN EGGESEKMEM
     FVNFCEDTIF EMNIAASISE PEGDGAEEED DEEEEEGGGD EGESGEGDEG NGEGEAPESA
     SAFAEFLKSV VNFFNMFTFR NLRRRYRKLR KMTVKDMIIG LVTFVYTVLM GILMFVYSIC
     KGFFTLIWKA LFGGGLVEGA KKMTVTEILA SMPDPTQDEV HGDLPPEPGA REVQDADGVA
     DLIDAVGGEE EEEDGEDREG GRLPGFNTPG GLGDMGETTP EEPPTPEGTP LLKRKLLAAA
     VGGQEEEEKG EHEEEAPQET EKADTENGEK TEKAEKAEPE PEVKEEEPEE QEEISVKTKV
     KKDKKSVKEG FKLWNELEVQ RIKFMNYLSR NFYNLRFLAL FIAFALNFIL LFYKVSDTPP
     GEEEFEGSGL FEGSGIFEGS GAEEDGSGLD DGGDDDDEEG PLYYFLEEST GYMEPAMAFL
     GIVHTIISFL CIIGYNCLKV PLVIFKREKE LARKLEFDGL YVTEQPEDDD IKGQWDRLVL
     NTPTFPNNYW DKFVKRKVLD KYGDIYGRER IAELLGMDLA SLDVSAMSHG KKPEPDTSMF
     SWITSIDIKY QIWKFGVVFT DNTFLYLVWY MLMSLLGHYN NFFFAAHLLD IAMGVKTLRT
     ILSSVTHNGK QLVMTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF
     HMYVGVRAGG GIGDEIEDPA GDEYELYRVV FDITFFFFVI VILLAIIQGL IIDAFGELRD
     QQEQVREDME TKCFICGIGS DYFDTTPHGF ETHTLEEHNL ANYMFFLMYL INKDETEHTG
     QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ LG
//
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