ID   I3J8F4_ORENI            Unreviewed;       678 AA.
AC   I3J8F4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Stress-70 protein, mitochondrial {ECO:0000256|ARBA:ARBA00019355};
DE   AltName: Full=75 kDa glucose-regulated protein {ECO:0000256|ARBA:ARBA00031419};
DE   AltName: Full=Heat shock 70 kDa protein 9 {ECO:0000256|ARBA:ARBA00030055};
GN   Name=hspa9 {ECO:0000313|Ensembl:ENSONIP00000005144.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005144.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000005144.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR   RefSeq; XP_003459471.1; XM_003459423.4.
DR   AlphaFoldDB; I3J8F4; -.
DR   STRING; 8128.ENSONIP00000005144; -.
DR   Ensembl; ENSONIT00000005148.2; ENSONIP00000005144.1; ENSONIG00000004081.2.
DR   GeneID; 100708580; -.
DR   KEGG; onl:100708580; -.
DR   CTD; 3313; -.
DR   eggNOG; KOG0102; Eukaryota.
DR   GeneTree; ENSGT00920000149123; -.
DR   HOGENOM; CLU_005965_2_1_1; -.
DR   InParanoid; I3J8F4; -.
DR   OMA; MGTDWKI; -.
DR   OrthoDB; 143at2759; -.
DR   TreeFam; TF105046; -.
DR   Proteomes; UP000005207; Linkage group LG2.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   CDD; cd11733; HSPA9-like_NBD; 1.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 3.30.30.30; -; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   NCBIfam; TIGR02350; prok_dnaK; 1.
DR   PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR   PANTHER; PTHR19375:SF184; STRESS-70 PROTEIN, MITOCHONDRIAL; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003322};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   REGION          655..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..678
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  73655 MW;  AB1B49D64F5F2978 CRC64;
     MLSVTRSVSR TLPTRSNIRS VSSLIKKACW TGFQPDALRA LSRRDYASEA VKGAVIGIDL
     GTTNSCVAVM EGKQAKVLEN AEGARTTPSV IAFTADGERL VGMPAKRQAV TNPQNTLYAT
     KRLIGRRFED PEVQKDLKNV PYKIVRASNG DAWVEAHGKM YSPSQAGAFV LMKMKETAES
     YLGSTVKNAV ITVPAYFNDS QRQATKDAGQ IAGLSVLRVI NEPTAAALAY GLDKTQDKII
     AVYDLGGGTF DISILEIQKG VFEVKSTNGD TFLGGEDFDQ HLLRHIVKEF KRESGVDLTK
     DNMALQRVRE AAEKAKCELS SSLQTDINLP YLTMDASGPK HLNMKLTRAQ FEGIVADLIR
     RTVAPCQKAM QDAEVSKGDI GEVLLVGGMT RMPKVQQTVQ DLFGRAPSKS VNPDEAVAIG
     AAIQGGVLAG DVTDVLLLDV TPLSLGIETL GGVFTKLINR NTTIPTKKSQ VFSTAADGQT
     QVEIKVCQGE REMATDNKLL GQFTLVGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG
     REQQIVIQSS GGLSKDDIEN MIKNAEKYAE EDRRRKDRVE AVNMAEGIIH DTESKMEEFK
     DQLPADECTK LKEEISKVRN LLTNKDSETG ENIKQAATDL QQASLKLFEM AYKKMAAERD
     STSSSSSSSE GEKKEGQQ
//