ID I3J8T1_ORENI Unreviewed; 1100 AA.
AC I3J8T1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN Name=LOC100706327 {ECO:0000313|Ensembl:ENSONIP00000005271.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005271.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005271.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; I3J8T1; -.
DR STRING; 8128.ENSONIP00000044885; -.
DR Ensembl; ENSONIT00000005275.2; ENSONIP00000005271.2; ENSONIG00000004188.2.
DR eggNOG; KOG1023; Eukaryota.
DR GeneTree; ENSGT00940000164853; -.
DR HOGENOM; CLU_001072_1_0_1; -.
DR TreeFam; TF106338; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF228; RETINAL GUANYLYL CYCLASE 1; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 472..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 492..807
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 879..1009
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 816..843
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1100 AA; 123696 MW; E87468FF33E46B44 CRC64;
FVLARNSNPC CLHNLSYHPR FESLSASWWR NWFLLPFLIV SFFPHQASAT TFTMALVGPW
TCDLLYSKAL PDLAASLAIN RINKNTYLNK GYWYDYKLIN EDCQSSRALA RFAGLKGYAA
AYLGPANPGY CSSAALYAKE WDLGHLSWAC LKPNMNKGHM YPTFMRPLPL SSHVLFTVLR
YFRWAHVAII SEESDVWEAT GHELASSLRA LGLPVKPVVT MENNKEGPRA ALTKVRETDR
VRVVIMCMPS VLIGGHAQYQ LLTTALAMRM IDRGYVFIPY DTLLYSLPYN DAPYYMLGND
TKLRKAYDGV LTITMDSGER NFYEAFKQAQ DSYEIRTSTP PEQVSPFFGT IYNMMYYTAM
AAEQARASEG RWVTGRILAD GEGGFEFEGF NQPLRAGRNG EGMQAQYVVL DYSGIGNTLY
STHSLHASHT DSKSGGLKYL GRSIHFAGST PSKDSTCWFS PYFACTGGIS SAAVFFLFLM
FISLIGFLVN IFLRYSFGGG GHSGGSTKVV LTLDDLVFIN TQVSKRKLND DSIAKSQGDM
KTPHHSVSGR SYLASTPDSS NVAVFEGDWV WLKKCPAGSV SCVYNNTESV FVKLREMRHE
NLNLLLGLFF DSGIFGVVIE HCTRGSLEDL LSNEEVRLDW MFKSSLLMDL IRGMKYLHHR
DIIHGRLKSR NCVVDGRFVL KVTDYGFNDI WIAQNIDTDE KPEDLLWTAP ELLRSSSQRR
RGTFAGDVYS FSIVCQEVVS RSAPFCMLDM PPKEIINKVK EPPPLCRPVI SVEEAPVDVI
QVMKQAWSEE PERRPTFDDI FKQFKSITKG KKTNIIDSML RMLEQYSSNL EDLIRERTEE
LEVERQKTDN LVAQMLPKSV AQALKTGKPV KPEHFNEITL YFSDIVGFST ISSLSEPIEV
VNLLNDLYSL FDAIILLHDV YKVETIGDAY MVASGVPNRN GNRHAAEMAN MSLDILHCIG
TFKARHMPDL KIRIRVGLHS GPVVAGVVGL TMPRYCLFGD TVNTASRMES TGLPYRIHVN
QSTVDVLKSL NLGYKIDVRG LTELKGKGIE TTYWLVGKED FTKPLPDPRD LPGGSTHVIS
LEEIPADRRQ KFLDRQKKTN
//
