ID I3J9T3_ORENI Unreviewed; 879 AA.
AC I3J9T3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Neuronal PAS domain-containing protein 2 {ECO:0000313|Ensembl:ENSONIP00000005623.2};
GN Name=LOC100691220 {ECO:0000313|Ensembl:ENSONIP00000005623.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005623.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005623.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005472028.1; XM_005471971.3.
DR AlphaFoldDB; I3J9T3; -.
DR Ensembl; ENSONIT00000005627.2; ENSONIP00000005623.2; ENSONIG00000004466.2.
DR GeneID; 100691220; -.
DR KEGG; onl:100691220; -.
DR CTD; 4862; -.
DR GeneTree; ENSGT00940000164304; -.
DR InParanoid; I3J9T3; -.
DR OMA; NQSHSAY; -.
DR OrthoDB; 2899615at2759; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0009648; P:photoperiodism; IEA:Ensembl.
DR CDD; cd19736; bHLH-PAS_PASD1; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR46055:SF4; CIRCADIAN CLOCK PROTEIN PASD1; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 36..88
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 111..181
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 289..336
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 29..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 544..578
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 429..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 879 AA; 99608 MW; C51F4F4E8D4E3A17 CRC64;
MDNLSDFGGP CPSGHREWDT NSCMDDLMDE DEKDRAKRAS RNKSEKKRRD QFNVLIKELC
TMLQGQGHPR KMDKSTILQR TIDFLQKQKD ITAQNDTCDV RQDWKPSFLS NEEFTQLMLE
ALDGFLVALT TDGNIIYVSD SVSSLIGHLP SDMVDQNILN FLPEREHGEV YKLLSSHMLM
TDPIAADFLD SEAHIEFCCH LARGNMNPKE PPVYEYVKFV GDFKFHNHVP TSSCNGLELT
LPRSLQSSLE EQVCLIATVR LVTPQFLKDL CNVEDPCDEF TSRHSLEWKF LFLDHRASPI
IGYLPFEVLG TSGYDYYHVD DLELIAQCHK QLMQFGKGKS CYYRFLTKGQ QWIWLQTHYY
ITYHQWNSKP EFIVCTHTVV SYAEVRAERR RAFGLEDLSP PEIAPSSVKA QELYLDICST
MDAPRDRNSG ARSVSSHSSR KSSHTALSDS ASANSYTEAC TPSWQSASIG PEKTSARFQP
SSSKNLAQRQ NSFDLVSPMS LPLSPTCSKH SAMQQQPQQQ QQQQQQSSMY QLQQPQLGVM
NQLKEQLEER TRILQADIKT QQQELHDIKE KLHLANLQML LQQPVNNDFS QAQQQQQQQQ
QPQQQQQGPG RPAQQSQSGV IRQLSGHPKP VCGAHSSSPH SLLRENSSPS TQVQPRVSRS
GQAQSVSLPV QTNTSLTMPF YSNPMMFSQT NTRPQQDANQ RHPDNQFSQD GQLRMLLNQP
MQTLVPTSVS SQPSQCNMGI SPSIYTLEQQ ILAPSFPMQQ VNCNAVLVPS PVFTSPIMIP
HNSFITHQSQ SAYHSQPQAS QHSLQLQQPQ QFFQMTQGLV HGGSTPAFLH TTNVPQQSTV
GYIQQPVAQQ QQAPQQQRQY QHSQNQTGSV SEYRNMLTR
//
