ID I3JA42_ORENI Unreviewed; 236 AA.
AC I3JA42;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Syntaxin-6 {ECO:0000256|ARBA:ARBA00044124};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005732.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005732.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00037867}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037867}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004409}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00037801}; Single-pass type IV membrane
CC protein {ECO:0000256|ARBA:ARBA00037801}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00043941}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00043941}.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
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DR AlphaFoldDB; I3JA42; -.
DR STRING; 8128.ENSONIP00000005732; -.
DR Ensembl; ENSONIT00000005736.2; ENSONIP00000005732.2; ENSONIG00000004553.2.
DR eggNOG; KOG3202; Eukaryota.
DR GeneTree; ENSGT00940000157639; -.
DR HOGENOM; CLU_061883_1_0_1; -.
DR InParanoid; I3JA42; -.
DR OMA; EHDPYRF; -.
DR TreeFam; TF313254; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR GO; GO:0048193; P:Golgi vesicle transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd15851; SNARE_Syntaxin6; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR015260; Syntaxin-6_N.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF104; SYNTAXIN-6; 1.
DR Pfam; PF05739; SNARE; 1.
DR Pfam; PF09177; Syntaxin-6_N; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..206
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
SQ SEQUENCE 236 AA; 26999 MW; C4C1B69A83187EE6 CRC64;
LNESDPHDDS VNAAQSLHHR WSELMAEGGG ASKEEIDWTT NELRNSLRSI EWDLEDLDET
INILQILRIV ESNPKKFNLD AAELSKRKAF INSTRVAVKV TLLTTGDQWL RQKDPPGADK
YSRLDHQLQN ANSQFIEEQQ VQQQLIAEQQ EEQLELVSGT IGVLKNMSER IGMELDEQAV
MLDDFGHEMD NTQSKLDNVM KKLAKVSHMT SDRRQWCAIG VLLTILFIII LLFFIL
//
