ID I3JAF7_ORENI Unreviewed; 1034 AA.
AC I3JAF7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Nardilysin {ECO:0000313|Ensembl:ENSONIP00000005847.2};
GN Name=LOC100693897 {ECO:0000313|Ensembl:ENSONIP00000005847.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005847.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005847.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR RefSeq; XP_005478812.1; XM_005478755.3.
DR AlphaFoldDB; I3JAF7; -.
DR Ensembl; ENSONIT00000005851.2; ENSONIP00000005847.2; ENSONIG00000004642.2.
DR GeneTree; ENSGT00940000155026; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 144..276
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 302..487
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 493..776
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 781..941
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..135
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 117745 MW; D755C67680F51064 CRC64;
MPQTSKSMSG AGAAAASVPD QGEPPPPEDA RAQVAAGDRE EGATVDDQGD PEIVKSPSDP
KRYRYIELSN GLRALLISDF SGADGEGGDG ESAEQEEEQE EEEGGEEDEG DSGEGSEEEE
GDRSEEEQDS DFEELEEENP VKKKKSSEKQ AAAALCIGVG SFSDPDELPG LAHFLEHMVF
MGSEKYPAEN GFDAFLKKHG GSDNASTDCE RTIFQFDVQR KHFRDALDRW AQFFICPLMI
EDAVDREVEA VDSEFQLARP SDSHRKEMLF GSLAKPGHPM GKFCWGNAQT LKHEPREKQI
NTYERLRDFW RRYYSAQYMT LAVQSKETLD TLEEWVREIF IRVPNNGEPR PDFSRLQQPF
DTPAFNKLYR VVPVRKVHAL TISWAVPPQG KHYRVKPLHY ISWLIGHEGT GSILSLLRKK
CWALALFGGN SETGFDQNTT YSIFSISITL TDQGYQNFYQ VVHFVFQYLK MLQTLGPQQR
IYEEIQKIEA NEFHYQEQVE TDPIEFVENI CENMQLFPKQ DFLTGDQLMF EYDPQVINAA
LSLLTPDRAN LLLLSPENEG CCPLKEKWFG TCYSMEDIPE EWAERWAGDF ELNPELHLPA
ENKFIATDFT LKTSDCPDTE YPVRIVNSER GCLWYKKDNK FKIPKAYIRF HLISPMIQKS
PENLVLFDLF VNILAHNLAE PAYEADVAQL EYKLVAGEHG LMIRLKGFNH KLPLLLQLIV
DQLADFSTEP SVFTMFSEQL KKTYFNILIK PDRLGKDIRL LILEHCRWSV IQKYRAVSKG
LTVDDLMTFV RGLKAELYAE GLVQGNFTSA ESKEFLRYFT EKLQFQPLPA EVPVLFRVVE
LPLKHHLCKV KSLNKGDANS EVTVYYQSGL KKLREHALME LMVMHMEEPC FDFLRTKETL
GYQVYPTCRN TSGVLGFSVT VETQATKFSS EFVEAKIEEF LVSFGERLSG LSDEAFGTQV
TALIKLKECE DAHLGEEVDR NWFEVVTQQY VFDRLNKEAG SGLTKPASDR ASAGEWSTDH
SLLQLGWAPP PLKF
//