ID   I3JAK4_ORENI            Unreviewed;       489 AA.
AC   I3JAK4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Angiopoietin-2 {ECO:0000313|Ensembl:ENSONIP00000005894.2};
GN   Name=LOC100709172 {ECO:0000313|Ensembl:ENSONIP00000005894.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005894.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000005894.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JAK4; -.
DR   Ensembl; ENSONIT00000005898.2; ENSONIP00000005894.2; ENSONIG00000004681.2.
DR   GeneTree; ENSGT00940000164972; -.
DR   HOGENOM; CLU_038628_3_1_1; -.
DR   Proteomes; UP000005207; Linkage group LG22.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   NCBIfam; NF040941; GGGWT_bact; 1.
DR   PANTHER; PTHR19143:SF243; ANGIOPOIETIN-2; 1.
DR   PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..489
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025611172"
FT   DOMAIN          268..488
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51406"
FT   COILED          176..228
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   489 AA;  55838 MW;  C9B390E612A90FC7 CRC64;
     MGRLLALTFA YLAYLLAIAI ASERQQHRVQ HGPCSYTFIL PEVEHCHPLK DFQVTNILQR
     DSPPEAEPSW QERKLQSLES AMENNTQWLQ KLENFINENV RSGVEEIKRT AVHTQTAAML
     EMGTNLLSQS AEQTRKLTDV ETQVLNQTSR LEIQLLEYSL FTNRLEKHIL LQTQEISRLS
     DKNSFLEQRL LALEGRYGRE LKGLQSEKQQ LQELLERQSQ LVGQLQRELG SSSLNSTLLQ
     RQQAMLTDTV QQLLAVASHC NEISNMPKEE PLSFRDCAEI LRSGVKESGI YSIRLHNSTQ
     TVKVFCDMKT RGGGWTVIQH RRNGSVDFHR GWRDYKTGFG EPSGEHWLGN DIIHKLTSSQ
     DYSLHVQLRD REGNEAYSHY DHFYIDGEEK NYSLHAEGFS GTAGRTSSLS HAGSQFSTKD
     RDNDRCTCKC AQLASGGWWF EACGPSNLNG IYYPASSSVV RYNSIKWYYW KGPNVIATMT
     TMMVRPANF
//