ID   I3JBA3_ORENI            Unreviewed;       746 AA.
AC   I3JBA3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC100698400 {ECO:0000313|Ensembl:ENSONIP00000006143.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006143.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000006143.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; I3JBA3; -.
DR   STRING; 8128.ENSONIP00000077520; -.
DR   Ensembl; ENSONIT00000006147.2; ENSONIP00000006143.2; ENSONIG00000004885.2.
DR   eggNOG; KOG2189; Eukaryota.
DR   GeneTree; ENSGT00950000182881; -.
DR   HOGENOM; CLU_005230_0_0_1; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000005207; Linkage group LG2.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF21; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 3.
PE   3: Inferred from homology;
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        364..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        417..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        516..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        543..567
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        608..631
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        707..732
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
SQ   SEQUENCE   746 AA;  85214 MW;  A78097D9101753D7 CRC64;
     MGSIFRSEEV CLVQLFLQSG SAYNCVSELG ELGLVEFRDL NPNVNSFQRK FVSEVRRCED
     LEKTFHFLEQ EINRSLSSPS KGPLPPPCPM PSAPQPRELI TIEEESERLA RELKEVSAEM
     EPEEVKCCLF PLYITVFLSL SFVAGVVHPW KVPSFERLLW RACRGYIIVD FREMEDRLEH
     PDTGEMVQWT VFLISFWGDQ IGQKVKKICD CFRTETFAYP ESSAEREEVL QGLQGRIEDI
     KSVLSQTESF LQQLLMKAVA VLPQWKVRVQ KCKAIQSVLN LCSPSVTDKC LIAEAWCPTA
     KLPELQCALR EGGRKSGSGV DSFYNRLPCS TPPPTLFPLN SFTAGFQNIV DAYGVAAYRE
     VNPALFTIIT FPFLFAVMFG DVGHGLLMTL TALWMVLEEK DPKLRNNNNE IWRMMFGGRY
     LILLMGLFSI YTGAIYNECF SKGLATFSSA WHVEHFRIFT LETYFSSVLA GSQYLSMDPA
     VPGVFTSPYP FGIDPVWGMA NNKLTFLNSY KMKMSVIIGI IHMTFGVCLS FFNYWHFRKF
     SSLIFVLIPE LFFMLFLFGY LVFMVVYKWV AYAPSQSKSA PSILIHFIDM FLFTENPDNP
     PLYRGQAIVQ KVLVILALCS VPFLLLGKPT FEYIMFKRRR RRVVSLRLEF DVADVFMHQA
     IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWEMVMR KGLTWQGYVG AVVLFVIFAF
     FAVLTVCILL VMEGLSAFLH ALRLHW
//