ID I3JBN6_ORENI Unreviewed; 452 AA.
AC I3JBN6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Bone morphogenetic protein 8a {ECO:0000313|Ensembl:ENSONIP00000006276.1};
GN Name=bmp8a {ECO:0000313|Ensembl:ENSONIP00000006276.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006276.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006276.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_003454659.1; XM_003454611.4.
DR RefSeq; XP_019206058.1; XM_019350513.1.
DR AlphaFoldDB; I3JBN6; -.
DR STRING; 8128.ENSONIP00000006276; -.
DR Ensembl; ENSONIT00000006280.2; ENSONIP00000006276.1; ENSONIG00000004988.2.
DR GeneID; 100709277; -.
DR KEGG; onl:100709277; -.
DR CTD; 353500; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000155272; -.
DR HOGENOM; CLU_020515_4_1_1; -.
DR InParanoid; I3JBN6; -.
DR OMA; DRDIFHQ; -.
DR OrthoDB; 2912454at2759; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000005207; Linkage group LG22.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF119; BONE MORPHOGENETIC PROTEIN 8A-RELATED; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 326..452
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 316..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 51002 MW; A743454D958425F8 CRC64;
MASVISYGLS CLFAKMPRTH TRSARSTSAI HPWTLLLLSL LLLLSLSLWS QQAEAVVPSS
FRKLSGREKK EMQKEILTIL GLPGRPRPHP PLRPPSSAPL FMLDLYHAMS VDEDEGNEII
ASTPFKGSSK GAPQVNRGAL PTLSTHTPPL GTVVSEADTV MSFVNLVEQE RDLLQPRPYW
KEFRFDLTPL PKGETVTAAE FRIYKTLTVG QRANRTLHIS VYEIKRENRH REPELVLLDM
QSVPAGQEGW LAFDVTSASN HWLVHPRSNM GIRLYVETEE DRSLAGGWIG LVGRRGPRSK
QPFMVTFFRE NQVPCRPPRA VKPHPRRKKP KYDLPVPNFK ERNSENRGQP CKKHELYVSF
SDLGWKDWVL APTGYSAYYC DGECFYPLGA CMNATNHALI QQVVHILKPD EVPKACCAPT
KLSPISVLFY DDNNNVILKK HRNMVVKTCG CL
//
