GenomeNet

Database: UniProt
Entry: I3JBT6_ORENI
LinkDB: I3JBT6_ORENI
Original site: I3JBT6_ORENI 
ID   I3JBT6_ORENI            Unreviewed;      5035 AA.
AC   I3JBT6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSONIP00000006326};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006326, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000006326}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000006326}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000006326}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AERX01016792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01016793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01016794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000006326; -.
DR   Ensembl; ENSONIT00000006331; ENSONIP00000006326; ENSONIG00000005030.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4315   4338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4546   4566       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4636   4657       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4778   4799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4837   4857       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4916   4939       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       96    151       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      158    203       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    266       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      272    329       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      337    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      599    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1210       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1348   1558       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1869   1899       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5035 AA;  570795 MW;  6AB9B206D31DD6C0 CRC64;
     MAEAADGEEE IQFLRTDDHV VLQCTASILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLSNSSVDES SQGGGHRTLL YGHAILLKHT HSSMYLSCLT
     TSRSLTDKLA FDVGLQEDST GEACWWTIHP ASKQRSEGEK VRVGDDLILV SVSSERYLHL
     SYASGDLMVD ASFMQTLWTM TPVMSGCELA EGFLTGGYVL RLFHGHMDEC LAIPAADQGD
     DQRRVAHYEG GPVCSHARSL WRLEPLRIAW SGGHIKWGQS FRIRHITTGR YLCLDEEKGL
     LLVDPEKANS KMSAFCFRIS KEKIEVTQKR DVEGMGIPEI KYGESMCFVQ HVSSGLWLTY
     AAVDAKSARL GPLKRKAILH KEGHMDDALT VARSQTEESQ AARMIYSTTG LFNQFIKGLD
     ALSGKNKSAN APSLPMDAVV LSLQDLIFYF RPPEEELEHE DKQFKLRSLK NRQNLFQEEG
     MITLVLDCVD RLNVYNTAAH FSEYAGEEAA ESWKEIVNLL YELLASLIRG NRANCALFCD
     NLDWLVSKLD RLEASSAIGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQNL ITENLLPGRD LLLQTNIINY VTSMRPNVFL GTCEGSTQYK
     KWYFEVMVDH VEPFLTAQPY HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWSGRVPRHV ATTNQHLLAA EDVVSCCLDL SVPSISFRIN GHPVQGMFEN FNLDGLFFPV
     VSFSAGIRLR FLLGGRHGHF KFLPPPGYAP CYEAVLPRDR LRIEPIKEYK HDFDGVRNLL
     GPTQSLSHTA FTPCPVDTIQ IVLPPHLERI REKLAENSHE LWAVTRIEQG WTYGPFRDDN
     KKLHPCLVDF QSLPEPEKNY NLAMSGETLK TLLALGCHVG MGDEKAEENL KRTKLPKTYM
     QSNGYKPAPL DLNHVKLTPN QNTLVERLAE NGHNVWARDR VRQGWTYSIV QDIMNKRNPR
     LVPYNLLDEK TKKTNRDTVC AAVRTLIGYG YNIEPPDQES SGHGPGSSRG DKIRVFRAEK
     SYAVTQGKWY FEFEAVTVGE MRVGWSRPNV RADTELGADE LAYVFNGFKA QRWHIGNEPF
     GRQWQSGDVV GCMIDLTEMN IMFTLNGEML ISDSGSEMAF KDIEIGEGFI PVCSLGLSQV
     GRINLGQNVS SLRYFTICGL QEGFEPFAIN MKRDITMWFS KSLPQFIPVP ADHPHIEVSR
     VDGTVDTPPC IKATHKTFGS QNANTDLLFF RLSMPVEFHE TFKIPAGTTL LTRTLTIPED
     EVLEVDPGSD FEILKKSATR KEQEEEKKET SVPKETPAIK NGENEKDAST EKSKKKGFLF
     KAKKAALITP PPVVPTMPRL VEDVVPDDRD DMDIILNTTT YYYSVRVFAG QELNGVWVGW
     ITPDYHQYDL HFDISKVRNV TVTVGDDKGN IHDSIKRSNC YIVWGGEFSS SQQTRVSQED
     FVIGCLIDLD TGLMTFTGNG KEINTFYQVE PTTKLFPAVF VLPSSQNMVQ LELGKLKNIM
     PISAAMFRSE RKNPVPQCPP RLDVQMLTPV IWSRMPNNFL APEMGRVSER LGWMVECTEP
     LTMMALHIPE ENRCIDILEL SERMDLLKFH YHTLKLYSSV CALGNNRVAH ALCSHVDESQ
     LFYAIENTYL PGPMRSGFYD LLISMHLESA KRNRLGTNKE FIVPMTEETR SITLYSDKSH
     ALPGVGLTTC LRPKLHFSSV GFVGTDQDIY TLSPVIPLQV LKTKALNMLT EAVQDGGQAM
     RDPVGGSVEF HFVPILKLIS TLLIMGVFDD EDVTHILKMI EPTVFRGKQA EEPVAAIKEG
     EQEALGEEEE EFEDDGLGYE EEEEELEEEE AIEEETGGEG KEEHLEQGLF QMKLPESVKL
     QMCTLLQYFC DCELRHRVEA IIAFSDQFVS QIQSNQRQRY NELMQAFTMS AAETARKTRE
     FRSPPQEQVN MLMNFKNSFE DEESPIPDEV RESLLAFHNT LLAHCGVHIE EEEQEEEVDN
     SVRGRLLRLL ERVKKFREKK EEVESEPQED KKPSTLQELI SHTMIHWAQE SFIQNPELVR
     MMFSLLHRQY DGLGELMRAL PKAYTINAVS IQDTMDLLEC LGQIRSLLIV QMGPEEERLI
     IQSIGNIMSN KVFYQHPNLM RALGMHETVM EVMVNVLGGG DSKEIRFPRV VTNCCRFLCY
     FCRISRQNQR SMFDHLSYLL QNSGIGLGMR GSTPLDVAAA SCIDNNELAL ALQEQDLEMV
     VKYLAGCGLQ SCPMLLAKGY PDIGWNPCGG EKYLDFLRFA VFVNGESVEE NANVVVRLLI
     RRPECFGPAL RGEGGNGLLA AIEEAIKISE DPARDGPSVK KDRRFPMFGG EEQHEENRVH
     LGNAIMSFYS ALIDLLGRCA PEMHLIQAGK GEALRIRAIL RSLVPIEDLV GVISLPLQIP
     AFGKDNSVIE PKMSASFVPD HKAPMVLFLD RVYGIDNQDF LLHVLEVGFL PDMRAAASLD
     TVAFSTTEMA LALNRYLCSA VLPLITKCAP LFAGSDHRAI MIDSMLHTIY RLSRGRAFTK
     AQRDIIEECL MALCKHLRPS MLQHLLRRLV FDVPILNEYA KMPLKLLTNH YERCWKYYCL
     PNGWANFGVA SEEELHLTRK LFWGIFESLA HKKFDAEIFK ISMPCICAIA GAIPPDYVDA
     SYSSKTEKKA SVDAEGNFDP KPVDTTNHST IIPERLDPFI NRYAEYTHDK WAFEKIQNNW
     SYGETLDENA KTHPMLRPYK TFSEKDKEIY RWPIKESIKA MIAWEWNIEK AREEEESEKK
     KATSRKISQT AQATYDPSHG YSPQPIDISH MALSRDLQSM AEQLAENYHN TWGRKKKLEL
     QAKGGGTHPL LVPYDTLTAK EKARDREKAY ELLKFLQLNG YAVTRGLKDM ESDISSIEKR
     FAYGFLQKLL KWMEIAQEFI AHLEAVVSSG RVEKSPHEQE IKFFAKILMP LINQYFKNHC
     LYFLSTPAKV LGSGGHSSNK EKEMIASIFC KMSALVRHRV SLFGTDAPAI VNCLHILARS
     LDARTVMKSG PEIVKAGLRS FFESAADDIE KMVENLKLGK VSKGNQQVKG VSQNINYTTI
     ALLPVLTSLF DHIAQHQFGD DVILDDLQMS CYRIMCSIYS LGTVKNLHVE RQRPALGECL
     AHLAAAMPVA YLEPHLNEFN AFSVYTTKTP RERAILGLPN EVQELCPDIP ELDTLLKEIG
     DLAESGARYT EMPHVIEITL PMLCNYLIRW WERGPENFPE MEGRLCTEVT SEHLNQLLGS
     IMKIVVNNLG IDEASWMKRL AVFSQPIVSR AKPEMLKSHF IPTMEKLKKR TSKVVAEEDH
     LRMEGKSEGD EEDGTIRDEF AVLCRDLYAL YPLLIRYVDN NRARWLTCPD PDAEELFRMV
     GEVFIFWSKS HNFKREEQNF VVMNEINNMS FLTADSKSKM SKGGDTEGGG SDTERTKKKK
     RGDRYSVQTS LIVAALKKML PIGLNMCSPA DQELINLAKI RYSLRDTDEE VREFLQNNLH
     LQGKVDNPSM RWQMALYKEM AGKAEDADAP PKVVKRVQEV SAVLYHLEVT EHPFKSKKMV
     WHKLLSKQRR RAVVACFRMT PLYNIPRHRA SNMFLEGYRR NWLHPEGFSF EDRMIDDLSK
     AMEQEEGDEE EEKETKPDPL HQLILHFSRT ALTEKSKLDT DHLYMAYADI MAKSCHIGEE
     EEGGEEMGEN AEDEMSFEEK EMEKQRLLYQ QSRLHNRGAA EMVLQMISAC KGETGPMVST
     TLKLGISILN GGNSEVQRKM LEYLKDKKDV GFFLSVQALM QTCCVLDLNA FERQNKAEGL
     GMVSEEGTNL NLDRDEKVMA DDEFTCDLFR FLQLLCEGHN NDFQNYLRTQ TGSTTTINVI
     ICTVDYLLRL QESISDFYWY YSGKDVIDEP GKKNFSKAMT VAKQIFNSLT EYIQGPCNGN
     QQSLAHSRLW DAIVGFLHVF AHMMMKLAQD SSQIGLLKEL LDLQKDMVVM LLSLLEGNVV
     NGTIARQMVD MLVESSSNVE MILKFFDMFL KLKDIVASDA FRDYVTDPRG LISKKDFQKA
     MDSQKQYSPS EIQFLLSCSE ADENDMINYE EFASRFQEPA KDIGFNIAVL LTNLSEHVPH
     DTRLQNFLEQ AESVLNYFRP FLGRIEIMGA SRKIERIYFE ISEVNRRQWE MPQVRESKRQ
     FIFDVVNEGG ESEKMEMFVN FCEDTIFEMN IASQISEQEE EEKGEEEDEG EEGGGEGGGG
     GEGNGGGDED NNGREGPHES TSAFADFINS MLSFLGIFTF RNLRRQYRRV RKMTFKEIVV
     ALSTFFWTIL MSILHFIYNV CKGIFMIIWQ TLFGGGLVEG AKNITVTEIL ASMPDPTQDD
     VHGDGPGEPR TGEEQDTGGV TDTGETGSGE EEEEDTQEKE GGRIPGMDAP GGLGDMGVEA
     PVEPPTPEGT PITKRKMAPE ETDASQKPPE PPPVEEPPTE PEKADAETGE KTEKECESKE
     EVEPEKPKKS AAKKDKKLKK GGGFQIWTEL ETQRNKFMNY LSRNFYNLRF LALFLAFALN
     FILLFYKVSD SPPEGEEMEG SGLSEGSGLF EGSALFEGSG EELEGSGING GGDEDEEDVP
     VYYYLEESTG YMQPTLSFLA MLHTVISFIC IIGYNCLKIP LVIFKREKEL ARKLEFDGLY
     ITEQPEDDDI KGQWDRLVLN TPSFPNNYWD KFVKRKVLDK YGDIYGRERI AELLGVDLAS
     LDVSQQHEKK QEEPDNSVFA WYRIQATSID IKYQIWKFGV VFTDGTFLYL CWYLVMSLLG
     HYNNFFFACH LLDIAMGVKT LRTILSSVTH NGKQLMMTVG LLAVVVYLYT VVAFNFFRKF
     YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF
     FVIVILLAII QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGSDYFDTTP HGFETHTFDE
     HNLANYMFFL MYLINKDETE HTGPESYVWK MYQERCWDFF PAGDCFRKQF EDQLS
//
DBGET integrated database retrieval system