ID I3JDA2_ORENI Unreviewed; 348 AA.
AC I3JDA2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=TNF receptor superfamily member 19 {ECO:0000313|Ensembl:ENSONIP00000006842.2};
GN Name=tnfrsf19 {ECO:0000313|Ensembl:ENSONIP00000006842.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006842.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006842.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_005474625.1; XM_005474568.3.
DR AlphaFoldDB; I3JDA2; -.
DR STRING; 8128.ENSONIP00000006842; -.
DR Ensembl; ENSONIT00000006847.2; ENSONIP00000006842.2; ENSONIG00000005447.2.
DR GeneID; 100692417; -.
DR CTD; 55504; -.
DR eggNOG; ENOG502QQHI; Eukaryota.
DR GeneTree; ENSGT00940000153259; -.
DR HOGENOM; CLU_050058_1_1_1; -.
DR InParanoid; I3JDA2; -.
DR OMA; GHTEPEC; -.
DR OrthoDB; 5405444at2759; -.
DR TreeFam; TF331385; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0014045; P:establishment of endothelial blood-brain barrier; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR GO; GO:0048922; P:posterior lateral line neuromast deposition; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR CDD; cd13418; TNFRSF19; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022342; TNFR_19.
DR InterPro; IPR034047; TNFRSF19_N.
DR InterPro; IPR047526; TNR19/27/EDAR.
DR PANTHER; PTHR12120; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12120:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 19; 1.
DR PRINTS; PR01969; TNFACTORR19.
DR SMART; SM00208; TNFR; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..348
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025607192"
FT TRANSMEM 168..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..72
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 33..72
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 74..114
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 74..114
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 307..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 49..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 348 AA; 38204 MW; 3862B43D7C962AE8 CRC64;
MVRMLQNTFS LVLTLHVLYS SLIHTRAEEQ TRECREQEYK DRFGNCKPCK QCDAGQELSK
ECGFGYGEDA RCVPCRSSRF KEDRSLQKCK PCLDCGLINR FQKGNCSTTS NAVCGDCLPG
YYRKTKLSGF QDMECIPCGD PPPPYEPNCS GRVNLVPLPS VVTSPRDMAL AAVICSALAT
VLLALLVLCV IYCKRQLLEK KPSAASLRSQ DCPYRGAELS CLDARWLHDF PQRPCCQCHL
GPGHTCGPVH LIPSLCCDES CSLGRSQGNS PFQSQMSLSE GNANMDEDLE GHAEAVCGAE
YFDEPAEGPV VVGEEQDEGE RCGLRDKSPE RSSRSCSEAV TDVPTQEG
//
