ID I3JEC2_ORENI Unreviewed; 381 AA.
AC I3JEC2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Glucose-fructose oxidoreductase domain-containing protein 2 {ECO:0000256|ARBA:ARBA00040293};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007213.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007213.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Promotes matrix assembly. {ECO:0000256|ARBA:ARBA00037474}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family.
CC {ECO:0000256|ARBA:ARBA00010928}.
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DR AlphaFoldDB; I3JEC2; -.
DR STRING; 8128.ENSONIP00000007213; -.
DR Ensembl; ENSONIT00000007218.2; ENSONIP00000007213.2; ENSONIG00000005724.2.
DR eggNOG; KOG2742; Eukaryota.
DR GeneTree; ENSGT00940000156501; -.
DR HOGENOM; CLU_023194_8_0_1; -.
DR InParanoid; I3JEC2; -.
DR OMA; EMPLPHL; -.
DR TreeFam; TF323246; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43818; BCDNA.GH03377; 1.
DR PANTHER; PTHR43818:SF8; GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 5..111
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
FT DOMAIN 133..357
FT /note="Gfo/Idh/MocA-like oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02894"
SQ SEQUENCE 381 AA; 41538 MW; 134346B622616F7B CRC64;
MLPGVGVFGT GSTARVLVPL LKAEGFEVHA LWGRSEEEAC CLAKELGIPF HTSRSDDVLL
HQDVDLVCIY IPPSMTRQIA VKALGIGKNV VCEKAATAVD SFKMVTAARY YPQLLSIMGN
TLRFLPAFVA MRQLLVEGYV GELQVCDVRV YGPSLLDQSY GWTCEELMGG GGLHTVGSAI
IDLLSYLTGT RAHRVHGLLR TFVQQNGLIR GIRRVTSDDF CFFQMLMGGT GSSGVCCTVT
LNFNMPGSFV HEVMVVGSTG RLIARGTELY GQRNGSKSEE LLVGDSGWVG PEVKEMPLPL
LQGLSSMVKA LRQSFQAQEE RRCWARGPVA TAPTFEDGLY VQTVVEAVKR SSSSGEWECV
EIMSHEPDPN QNLHLTLPLF S
//
