ID I3JEE6_ORENI Unreviewed; 534 AA.
AC I3JEE6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Mannosyltransferase {ECO:0000256|RuleBase:RU363075};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363075};
GN Name=pigb {ECO:0000313|Ensembl:ENSONIP00000007237.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007237.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007237.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-
CC GlcN-acyl-PI during GPI precursor assembly.
CC {ECO:0000256|ARBA:ARBA00025591}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU363075}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 22 family.
CC {ECO:0000256|RuleBase:RU363075}.
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DR AlphaFoldDB; I3JEE6; -.
DR STRING; 8128.ENSONIP00000029851; -.
DR Ensembl; ENSONIT00000007242.2; ENSONIP00000007237.2; ENSONIG00000005742.2.
DR eggNOG; KOG1771; Eukaryota.
DR GeneTree; ENSGT00950000183090; -.
DR HOGENOM; CLU_012353_2_0_1; -.
DR TreeFam; TF313518; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR PANTHER; PTHR22760; GLYCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR22760:SF4; GPI MANNOSYLTRANSFERASE 3; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU363075};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363075};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363075};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363075}.
FT TRANSMEM 210..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 329..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 351..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 377..395
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
SQ SEQUENCE 534 AA; 61961 MW; 9FEE19280D782418 CRC64;
LARPCRQAWS SVCLHFVLLK LIDVKLRRRK SQLYSRQEAS PLNIGVLSVT VFCVVFRLIN
CLLVQTSFVP DEYWQSLEVS HRMVYKYPFW ETPLTEGTAG IRGFSYPLLF AFLYKILQFI
SYDSVQLLIW LPRSLQSLLA SFADVKFFFL LQTLENQDVA RWTFFCHMCS WFTWFCCTRT
LTNSMEATIT TLALSYFPLP GSKTHSSKKY LALVALAVII RPTAVIVWFP LLLYHFWQED
NKLRLITHNY IPIGTLALVT STTIDCFFYE KWTPVQFNFL KFNILHSVAD FYGSHPWHWY
LTQGFAVVIG PHLPLFLHGC MLAFKRYKIL LAAVVWTIAV YSLLPHKEFR FIYPVLPFCM
VFCGISLAHL KSWRRPAAAV LLSANLIPAL YTGLIHQRGT LDVMSHLQPL CDVGNVSTTR
PQPDVLFLMP CHSTPFYSHI HCPVKMRFLE CPPDLGEEAY VDEAERFYEE PLLWFRTSFP
YESSLPTHLI MFDVLEKEIS AFLEGNNFVR AAKIFHTHFP EGRVGGSIFI YERH
//
