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Database: UniProt
Entry: I3JET8_ORENI
LinkDB: I3JET8_ORENI
Original site: I3JET8_ORENI 
ID   I3JET8_ORENI            Unreviewed;       657 AA.
AC   I3JET8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Potassium voltage-gated channel, KQT-like subfamily, member 1 {ECO:0000313|Ensembl:ENSONIP00000007379};
GN   Name=LOC100697082 {ECO:0000313|Ensembl:ENSONIP00000007379};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007379, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000007379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000007379}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000007379}.
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DR   EMBL; AERX01024929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01024930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSONIT00000007384; ENSONIP00000007379; ENSONIG00000005859.
DR   eggNOG; KOG1419; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00550000074513; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF109; PTHR11537:SF109; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01460; KCNQ1CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM    116    138       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    150    170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    191    209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    256    277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    289    309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    321    347       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      119    348       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      490    604       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
SQ   SEQUENCE   657 AA;  73696 MW;  F04FD5BEB78FC77F CRC64;
     IMSNSSDPRQ ENTRRGSGLA RGKRPPDLEL SEITFSEPET GTPVGNNTFC ERDKMPEDGC
     TPNDIPPVHL HPYFSHPRMS VRMSVYSTGV RPVLTRTYIQ GRVYNFLERP SGWKCFVYHF
     TVFLIVLACL ILSVLSTIQQ YQALAHTTLF WVEIVLVVFF GVEYFVRLWS AGCRSKYVGI
     WGRLRFARKP ISVIDLIVVV ASIIVLSVGS KGQVFATSAS TRGIRFLQIL RMLHVDRQGG
     TWRLLGSVVF IHRQELITTL YIGFLSLIFS SYFVYLAEKD AVDSSGTTGF GNYADALWWG
     VVTVTTIGYG DKVPQTWIGK TIASCFSVFA ISFFALPAGI LGSGFALKVQ QKQRQKHFNR
     QIPAAACLIQ TSWRCFAVEN FDSATFKMFL RKRSNIPASS LSTPKPKKSV KMRKKLKSSD
     KDNGPTSPTV PSITFDSVFD SGRECHLRVS VGERAVKRSP GLLEVHSPST LQRNCSFADD
     MELEPERENE LAPASSVSQL TEPHRKAIRV IQRMRYFVAK RNFQQARKPY DVRDVIEQYS
     QGHLNLMVRI KELQRRLDQS LGKITLFQTG SDRAKDKGNN SIGSRLNRME DKITHMDQSL
     NRIAESLAYL LEQKDAGGGE GGGRSRLGRT CNVLPSQDSL PSYDQLSSPS LYASNTA
//
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