ID I3JFX5_ORENI Unreviewed; 889 AA.
AC I3JFX5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSONIP00000007766.2};
GN Name=ASAP1 {ECO:0000313|Ensembl:ENSONIP00000007766.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007766.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007766.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3JFX5; -.
DR STRING; 8128.ENSONIP00000007767; -.
DR Ensembl; ENSONIT00000007771.2; ENSONIP00000007766.2; ENSONIG00000006169.2.
DR eggNOG; KOG0052; Eukaryota.
DR GeneTree; ENSGT00940000158547; -.
DR HOGENOM; CLU_007265_3_5_1; -.
DR OMA; HYCCIYE; -.
DR TreeFam; TF300304; -.
DR Proteomes; UP000005207; Linkage group LG9.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08848; ArfGap_ASAP1; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR CDD; cd11965; SH3_ASAP1; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR038016; ASAP1_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF2; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 278..367
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 391..512
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 549..584
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 827..889
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 640..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..730
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..777
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 99875 MW; 81D529BD596A11C6 CRC64;
MSKQKELLRN LNPKTDSKNI YNSLPGRCVC TCRRTLVFFP VRMSLKVIAF KLTTAPPPFL
YTDHVQNEEN YAQALDKFGS NFISRDNPDL GTAFVKFSSL TKELSALLKN LVSPFADSCS
SVFLQDIKKP FDKAWKDYEA KFTKIEKEKR EHAKQHGMIR TEITGAEIAE EMEKERRLFQ
LQMCEYLIKV NEIKTKKGVD LLQNLIKYYH AQCNPLCFPL ISLLHYLQIK QTQDEEKKQL
TALRDLIKSS LQLDQKEDSQ SKQGGYSMHQ LQGNKEFGSE KKGYLLKKSD GLRKVWQRRQ
CSVKGGILTI SHATSNRQPV KLNLLTCQVK PSTEDRKCFD LISHNRTYHF QAEDEQDWIS
VLTNSKEEAL NMAFRGEQSS GGEDGLEDLT KAIIEDVLRM PGNEVCCDCG AADPKWLSTN
LGILTCIECS GIHREMGVHI SRIQSMELDK LGTSELLLAK NVGNSSFNEI MEGNLPSPSP
KPTPSSDMTV RKEFINAKYV DHKYARKTCT SAAAKMIELF EAVQSRDLLA LIQVYAEGVE
LMEPLPEEAG ETALHYSVRT ADQTSLHLVD FLVQNSGNLD KQTEWGNTAL HYCCMYEKPE
CLKLLLRGKP ATDITNQNGE TALDVARRLR NTQCEEAVST GPTSWISYLP PEVFQKSPPP
AETPQKVPLV ERPQPGDLPP KPQVSELPPK PGDLPPKPQL SDLPPKPQLG DLPPKPQLKD
LPPKPHLADI PPKPGSVESA PRAPHGEPTP RPQIQPPPPP QTHPQPQPQP HPQPQDSPSP
NQQANIGTPS QQSAEDTNGT PAGTQETPVP LPRKITTVWT RIFFQRNKAR RVKTIYDCQA
DNDDELTFVE GEVIIVTGEE DQEWWIGHIE GDPERKGVFP MSFVHILSD
//
