ID I3JG46_ORENI Unreviewed; 686 AA.
AC I3JG46;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Melanoma cell adhesion molecule {ECO:0000313|Ensembl:ENSONIP00000007837.2};
GN Name=mcam {ECO:0000313|Ensembl:ENSONIP00000007837.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007837.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007837.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019223025.1; XM_019367480.1.
DR AlphaFoldDB; I3JG46; -.
DR Ensembl; ENSONIT00000007842.2; ENSONIP00000007837.2; ENSONIG00000006220.2.
DR GeneID; 100699942; -.
DR CTD; 338313; -.
DR GeneTree; ENSGT00940000155838; -.
DR HOGENOM; CLU_028888_3_0_1; -.
DR OrthoDB; 5313595at2759; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR45889; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45889:SF8; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08205; C2-set_2; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 612..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 212..315
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 321..400
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..490
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 497..581
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 686 AA; 76164 MW; 67FEFE16C265662E CRC64;
MTRAERLSLQ RVSAPFCIIC LSTLRRHSSL SLCTVFQEDQ FLSDSFHTHT HTHAHTPQHG
HLQHRPIVMA LPDTAPLLVG LLLIFHALGA WAIVEVNMED KVEVMAGDTA QITCMFTTDE
GLGGTTIQWF YVLPNKKRQR IYNKEPMHEA AEQNTPFTDR ISLNVTGTAA VLVIRDVGVK
DNLEFICVIK TITPEEAEGR TQLQVFKSPT FPTIEAVETG VSVNEEDPSK IGSCSVKNGY
PKPNITWYRN NMPLRITPDE VDLKSSITTE SSGLYSVQSE LRMKVKKEDK DAKFYCEVLY
FVPGATKMTE SQHINITVYY PPTEVNIWVE SPKGKIKEGD TLELRCENNG NYPSSITTIK
HQNSGYFVEN NKMVQTNVTR LDGGVYECTF METDNFEEIS GSTKVLVNYL ESAVITPKDS
ITVMEEEELK ASCNALSSLQ TDITWFKNEK LVSKGNSLSV KSATFETAGM YKCVVTVPEM
EGMKTSSTLQ VNVKGSPQIL GPGVQEVETY ETTVNLNCSA RGFPAPTIMW TTSDGKNLNA
LQTETEDGAQ SVVTFKITSS VKVFCNASND FGSKVVEFNI KAITQNTSTN YVNDPVQTPT
KSPNIKKESK GFVIAIIIIA ILLLAILGSV LYFLYKKGRI CGRSGKQDFS KRKSSKDNIV
VEMKSDNTEE AILLGVNGEK QQPNDQ
//
