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Database: UniProt
Entry: I3JGF2_ORENI
LinkDB: I3JGF2_ORENI
Original site: I3JGF2_ORENI 
ID   I3JGF2_ORENI            Unreviewed;       976 AA.
AC   I3JGF2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 5a {ECO:0000313|Ensembl:ENSONIP00000007943};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007943, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000007943}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000007943}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000007943}.
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DR   EMBL; AERX01036138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01036139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01036140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01036141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000007943; -.
DR   Ensembl; ENSONIT00000007948; ENSONIP00000007943; ENSONIG00000006300.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; I3JGF2; -.
DR   OMA; GFNEYVH; -.
DR   OrthoDB; EOG091G029I; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005461; TRPC5_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF24; PTHR10117:SF24; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    328    352       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    403    420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    441    461       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    481    500       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    521    543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    600    622       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       62     93       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT       69     93       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   COILED      227    254       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   976 AA;  111347 MW;  62C4CEA1A8FC1EED CRC64;
     MTQLYYKKAT YSPYRDRIPL QIVRAEVELS AEERAYLTAV EKGDYAGVKH ALREAEVYYN
     MDVNCLDPLG RSALLIAIEN ENLEIMELLL DHGIHTGDAL LYAIRKEVVG AVELLLSHKR
     PSGEKQVPSL MMDSQFSEFT PDITPIMLAA HTNNYEIIKL LVQRKVTIPR PHQIRCDCVE
     CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFRQE
     YEELSQQCKR FAKDLLDQAR SSRELETILN HRDNDQSEEL DPRQCHDLAK LKLAIKYHQK
     EFVAQPNCQQ LLATLWYDGF PGWRRRHWVV KLVTCFIIGL LFPVFSLIYL LAPKSALGRF
     IKKPFIKFIC HTASYLTFLF LLLLASQHIA RTNLHMQGPP PTIVEWMILP WVLGFIWAEI
     KEMWDGGFTE YIHDWWNLMD FAMNSLYLAT ISLKIVAYVK YNSSRPREEW EMWHPTLIAE
     ALFAIANIFS SLRLISLFTA NSHLGPLQIS LGRMLLDILK FLFIYCLVLL AFANGLNQLY
     FYYETKASEE PNNCKGIRCE RQNNAFSTLF ETLQSLFWSI FGLLNLYVTN VKARHEFTEF
     VGATMFGTYN VISLVVLLNM LIAMMNNSYQ LIADHADIEW KFARTKLWMS YFDEGGTLPP
     PFNIIPSPKS FWYLLMWLHN KLCRTGQPPG EEPHKCENLR EFTERHADSL RQNQHYQEVI
     RNLVKRYVAA MIRSAKTDEG LTEENFKELK QDISSFRYEV LDLLGNRRPP RRNYSSSSET
     TKDDGAMASE DDSESGEGTG GGLGVQRSKS VTFMTPAEDD TKPTPTLGVS ALVRSISGMT
     QIERGVGPSA KTDSFKRLSY LFSRSKRKAP PMPVPVQSPV SYTISDGLLR PLGSHSHSDF
     GLSNVTRSET HLNEMGRSVD ISNPSFSPRR TNGRDSLLTL PLPPPCPCQS LHCASNMSES
     SSRLLDSSED VFQSGG
//
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