GenomeNet

Database: UniProt
Entry: I3JIE2_ORENI
LinkDB: I3JIE2_ORENI
Original site: I3JIE2_ORENI 
ID   I3JIE2_ORENI            Unreviewed;       532 AA.
AC   I3JIE2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE            EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN   Name=LOC100694977 {ECO:0000313|Ensembl:ENSONIP00000008636.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008636.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000008636.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001062};
CC   -!- SIMILARITY: Belongs to the glutaminase family.
CC       {ECO:0000256|ARBA:ARBA00011076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; I3JIE2; -.
DR   STRING; 8128.ENSONIP00000062373; -.
DR   Ensembl; ENSONIT00000008641.2; ENSONIP00000008636.2; ENSONIG00000006844.2.
DR   eggNOG; KOG0506; Eukaryota.
DR   GeneTree; ENSGT00390000010463; -.
DR   HOGENOM; CLU_016439_1_0_1; -.
DR   TreeFam; TF313359; -.
DR   Proteomes; UP000005207; Linkage group LG5.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.238.210; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   HAMAP; MF_00313; Glutaminase; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR041541; Glutaminase_EF-hand.
DR   NCBIfam; TIGR03814; Gln_ase; 1.
DR   PANTHER; PTHR12544; GLUTAMINASE; 1.
DR   PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF17959; EF-hand_14; 1.
DR   Pfam; PF04960; Glutaminase; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          10..93
FT                   /note="Glutaminase EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF17959"
FT   REPEAT          450..472
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ   SEQUENCE   532 AA;  59640 MW;  C882D6500E981BC0 CRC64;
     MHSKPSGSGV ENMLFYTITE GKEQVPISYF TAALKKNGLH PSDPRLKDCM EKLRQAVKES
     VGEVMMDKDL FHRCVGGNIV LLIQAFRKKF IIPEFDLFVQ KINEIYEKVQ KQSDGKVADY
     IPQLAKFSPE LWGVSLCTVD GQRHSVGHTK QPFCLQSCVK PLQYAIAVHE SGTEKVHRYV
     GMEPSGLKFN VLSLDDEDKP HNPMVNAGAI LISSLIKIFF FQVMEFVKKM AGQEYVGFSN
     ATFQSEKETG DRNFAIGYYM KEKKCFPLGA DMIDALDFYF QLCSIEVTCE SGSIMAATLA
     NGGICPITGE RVLSTEAVRN TLSLMHSCGM YDFSGQMAFH VGLPAKSGVS GAILLVIPNV
     MGVMCWSPPL DRVGNSVRGI HFCQELVSVF NFHNYDNLRH FVKKQDPRRQ DGDDRNKSVF
     NLLFAAYSGD VSALRRFALS SMDMDLKDYD SRTALHVAAA EGHMDVVKFL TETCKVDPFV
     EDRWGNLPVD DAMQFGHDKL VKVLKDYQQE CMQQEKKQSE ACSATQREID AT
//
DBGET integrated database retrieval system