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Database: UniProt
Entry: I3JJN6_ORENI
LinkDB: I3JJN6_ORENI
Original site: I3JJN6_ORENI 
ID   I3JJN6_ORENI            Unreviewed;      2120 AA.
AC   I3JJN6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009080, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000009080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000009080}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000009080}.
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DR   EMBL; AERX01062070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01062071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000009080; -.
DR   Ensembl; ENSONIT00000009085; ENSONIP00000009080; ENSONIG00000007200.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; I3JJN6; -.
DR   OMA; LIQVERP; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR   GO; GO:0097470; C:ribbon synapse; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR   GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     90    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    180    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    262    285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    341    362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    374    396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    516    534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    554    577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    646    666       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    720    745       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    837    855       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    867    890       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    954    987       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1037   1058       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1079   1105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1159   1177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1189   1209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1284   1302       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1376   1399       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1533   1567       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2120 AA;  240763 MW;  8AD55213ACCC488D CRC64;
     APAPGPAPAP ASAPAPAPTA PPAPPAPPAP TSSTIPVGAL AQKKRQQYAK SKKQGSNANS
     RPPRALFCLN LNNPIRRACI SLVEWKPFDI FILIAIFANC MALAVYVPFP EDDSNSTNHD
     LGTKGHKHFY FESTVTLAPL PVLETVEYAF LIIFTIETFL KIIAYGLVMH QNAYVRNGWN
     MLDFVIVVIG LFSVALELLT KEEKGEVEGD AHASMHGHGG KPGGFDVKAL RAFRVLRPLR
     LVSGVPSLQV VLNSIIKAMV PLLHIALLVL FVIIIYAIIG LELFIGKMHA TCYFPGSDMI
     AEEEPAPCAI SGHGRQCPIN GTECREGWQG PNGGITNFDN FLFAMLTVFQ CITMEGWTDV
     LYWMNDAMGF ELPWVYFVSL VIFGSFFVLN LVLGVLSGHR EFSKEREKAK ARGDFQKLRE
     KQQLEEDLKG YLDWITQAED IDPDNEDEAD EESKRNPSVP ASETESVNTE NQNGEDEKTP
     CCGPLCQKIS KSKFSRRWRR WNRFCRRKCR LAVKSVPFYW LVIILVFLNT LTISSEHYNQ
     PLWLTQVQDV ANKVLLALFT CEMLVKMYSL GLQAYFVSLF NRFDCFVVCG GITETILVEL
     EIMSPLGISV FRCVRLLRIF KVTRHWQSLS NLVASLLNSM KSIASLLLLL FLFIIIFSLL
     GMQVFGGKFN FDETQTKRST FDNFPQALLT VFQILTGEDW NAVMYDGIMA YGGPSSSGMI
     VCFYFIILFI CGNYILLNVF LAIAVDNLAD AESLNTDEDK KDDDKDDKLS FKDEDEDNDD
     TAAEEEDPEV PSGPRPVISD LVKKEKITPI PEGSAFFIFS NTNPVRVFCH RLINHHIFTN
     LILVFIMLSS VSLAAEDPIR NFSARNIVLG YADYVFTSMF TFEIVLKMTT YGAFLHKGAF
     CRNYFNLLDL LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV
     AIRTIGNIMI VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS SPVECKGTYI LYKDGDVNQP
     TVHKRVWHNS DFNFDNVLMA MMALFTVSTF EGWPALLYKA IDSNRENLGP IYNYRVEISI
     FFIIYIIIIA FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL KARPLRRYIP
     KNPYQYKFWY VVNSTGFEYI MFVLIMLNTL CLAVQHYGQS ALFNYVMDIL NMVFTAVFTV
     EMVLKLIAFK PRHYFADAWN TFDALIVVGS VVDIAITEVN NTEDSARISI TFFRLFRVMR
     LVKLLSRGEG IRTLLWTFIK SFQALPYVAL LIAMLFFIYA VIGMQVFGKI AMVDGTHINR
     NNNFQTFPQA VLLLFRCATG EAWQEIMLAC MPGKLCDPES DYNPGEEMTC GSGFAIVYFI
     TFYMLCAFLI INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWSEYDPE AKGRIKHLDV
     VTLLRRIQPP LGFGKLCPHR VACKRLVAMN MPLNSDGTVM FNATLFALVR TALKIKTEGN
     LEQANEELRA VIKKIWKRTS MKLLDQVVPP AGDDEVTVGK FYATFLIQDY FRKFKKRKEE
     GLVGAHPSQN NTAIALQAGL RTLHDIGPEI RRAISCDLQD DELIDFIPEE DEEIYRRNGG
     LFGNHLMNGG HRRSNGHQTN ATQRPLQVQP PPHYAHMEQP VGRLSRANAM SHPNHHHHHH
     HHHHHRHHNS YGKSPKSTNI NLNNANVSSL PNGGHHRYYE HAPPNGYPGL RSSYYDYDKP
     RTPQGQRRRY YETYVRSHRG DGHHPTIRRE EEFDEDRFSG EYYSGEEFYE DDSMLSGDSF
     AVCNCSFILT WLEIYSKGVL DNGSHNVMFP RYQNSDTEYE TPKGYHHPDS YYDDDEQPLY
     RDSRRSPKRR LLPATPQGHR RPSFNFECLR RQSSHDELPH QRTALPLHLM QHQVMAVAGL
     DSSRAHRLSP TRSTRSWATP PATPASKDQS PYYTPLIRVE HPHRESVVGS QVSVRKSSWY
     TDDPEFSQRT YSPVHLQVPP EYHNQYHQKR GSATSLVEAV LISEGLGRYA KDPKFVAATK
     HEIADACEMT IDEMESAASH LLNGGISPGI NGVNVFPLLT PRDYELPDTA ASYSDEEPET
     EPRGPYEEDL ADEMICITTL
//
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