ID   I3JKU9_ORENI            Unreviewed;       656 AA.
AC   I3JKU9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000009493.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000009493.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JKU9; -.
DR   Ensembl; ENSONIT00000009499.2; ENSONIP00000009493.2; ENSONIG00000034716.1.
DR   GeneTree; ENSGT01100000263487; -.
DR   HOGENOM; CLU_002274_4_5_1; -.
DR   InParanoid; I3JKU9; -.
DR   OMA; VHISITI; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM01288; FISNA; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          149..283
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   656 AA;  74901 MW;  B7B9F74FAA8ED850 CRC64;
     MFLFVFLESY QKCEPKLDSK QMKKFNYNNS SKESFVKITA TILKRMKLNK QADHLLSRSP
     SGRCQRKLKS ALKKKFQCVF EGIAKAGNPT LLNQIYTELY ITEGGTAEVN DEHEVRQIET
     ASRKPDRPET TIRQEDIFKD SPGRDEPIRT VLTKGVAGIG KTVLTQKYTL DWAEDKANQD
     IQFIFPFTFR ELNVLKEEKF SLVGLVHHFF TETKEAGICS FEDFQVVFIF DGLDECRLPL
     DFHKTTILTD PRKSTSVDVL LINLIRGKLL PSARLWITTR PAAANQIPPQ CVDMVTDVRG
     FTDPQKEEYF RKRFRDEEQA SRIISHIKTS RSLHIMCHIP VFCWITATVL EDVLETREGG
     QLPKTLTEMY IHFLVVQAKV KKVKYDGGAE TDPHWSPESR KMMESLGKLA FDQLQKGNLI
     FYESDLTECG IDIRAASVYS GVFTQIFKEE RGLYQDKVFC FIHLSVQEFL AALHVHLTFI
     NSGLNLLEEQ TTSKNSETRE SAEKHFYQSA VNKALQSPNG HLDLFLRFLL GLSLQTNQTL
     LRGLLTQTGS SSQTNQETVQ YIKEKLSENL SAEKSINLFH CLNELNHRSL VEEIQQSLRS
     GSLSTDKLSP AQWSALVFIL LSSEKDLDVF DLKKYSASEE AFLRLLPVVK ASNKAL
//