ID I3JMH2_ORENI Unreviewed; 899 AA.
AC I3JMH2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Nucleotide binding oligomerization domain containing 1 {ECO:0000313|Ensembl:ENSONIP00000010066.2};
GN Name=NOD1 {ECO:0000313|Ensembl:ENSONIP00000010066.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010066.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000010066.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; I3JMH2; -.
DR Ensembl; ENSONIT00000010075.2; ENSONIP00000010066.2; ENSONIG00000007993.2.
DR GeneTree; ENSGT00940000157845; -.
DR HOGENOM; CLU_011291_1_0_1; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08324; CARD_NOD1_CARD4; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF18; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 22..88
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 196..336
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 899 AA; 101221 MW; A250DC2364C24544 CRC64;
SVGDCCPVNM DQIKEARVPC SSLLTYHREL LVTRLRSIQC ILDNLFTCGF FCQEDVEIVQ
QTATKADQVR KILELVQCKG EEACEYLIFI IYKVCDAYID LQPWLKEINY NPSEDVTVMK
VVNTDPISRY CEKLRHDMSR DTSFIMSYGQ QEETRLEDLY TDTVMELLND CNESLGFLES
VDQLLGDHAV FNPQGEITYI MGDAGVGKSI LLQKLQNLWS TKELQTDAIF FFKFRCRMFS
TFKDAEQISL RDLLFKHNCY PDHDPDNEVF DYILRFPEKV VFTFDGYDEI QEDVDLMNLP
EVVSPEDKAN PLQLLISLLC GKLLKGSQKV LTARTGIEIQ SKVIRKKVAL RGFSPDHLKT
YTDLHFKEQE HRELVSIQLD ASPHLWGLCS TPLFCWIVFK SFGHLHTMHD SFHLPETCIT
LTDIFLLLSE VFLSRSATPA PSLLKKSTRC TSETFKAGLR PLVAFAKLAL QGMERGSFIS
SQEEISECGV TEEDLTLGFL RPLSEEDTSG SSATFEFLHM TLQSFLAAFA LVLDEQAAAS
SILKFFTECS RRRKVSCLPL DSCISSSSKP SEKKPFASNE HLQFTNLFLC GLLSKSQRSL
MGHLVSPVLL KKKRALLKSY LSTSVKFHLR GLPHYDGQEG KKVHVLPNFL WMLRCIFETG
SKDIAEMTAK GITAGFIKLG YCNVYSGDCT ALNFVLQHRQ KLLGLDMDNN NISDYGVKQL
KPSFCKMTVV RLCVNHLSDR SIEILAEELC KHKVVEVLGL YNNNITDAGA RLVAQIIEEC
PKLRVLKIGK NKITSVGGRH LANAIKKSSS IFDVGMWGNS IGDEGAEAFG EALRNHPSLT
NLSLSANCIT SRGGRGLAEA LKENTALRIF WLVENEMTDD AAPHLADMIQ ANTGLTHLW
//
