ID I3JPB5_ORENI Unreviewed; 752 AA.
AC I3JPB5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Cytoplasmic polyadenylation element binding protein 4 {ECO:0000313|Ensembl:ENSONIP00000010709.2};
GN Name=CPEB4 {ECO:0000313|Ensembl:ENSONIP00000010709.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010709.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000010709.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RRM CPEB family.
CC {ECO:0000256|ARBA:ARBA00010347}.
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DR AlphaFoldDB; I3JPB5; -.
DR Ensembl; ENSONIT00000010718.2; ENSONIP00000010709.2; ENSONIG00000008518.2.
DR eggNOG; KOG0129; Eukaryota.
DR GeneTree; ENSGT00940000154998; -.
DR HOGENOM; CLU_014948_2_1_1; -.
DR TreeFam; TF317658; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR CDD; cd19757; Bbox1; 1.
DR CDD; cd12724; RRM1_CPEB2_like; 1.
DR CDD; cd12726; RRM2_CPEB2_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.640.40; Cytoplasmic polyadenylation element-binding protein, ZZ domain; 1.
DR InterPro; IPR032296; CEBP_ZZ.
DR InterPro; IPR038446; CEBP_ZZ_sf.
DR InterPro; IPR034819; CPEB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR12566; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB; 1.
DR PANTHER; PTHR12566:SF2; CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 4; 1.
DR Pfam; PF16366; CEBP_ZZ; 1.
DR Pfam; PF16367; RRM_7; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 495..582
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 603..681
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 73..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 81847 MW; 91124F3CCDDB9B7A CRC64;
MPCLCALLSI GPNDHGIALV CGGRKQMGDY GFGVLVQNNT GNKSAFPVRI HPHLQPPHHH
QNVSQSPAAF INSTTAAGNG TTGGSPWLFP ASATHNSVQD EILGGPEKPK AQQQQEMQET
QEKQQLSPGS HQEGGSGGGI ISELEKARSD EGKTENGTSD SSNGKEKQLR LESPVLTGFD
YQETSGLGGT GPVQSSTTSS SLSGFNNWSP AIPPAPSTII NEDVSFFNPA SASNGPLLFQ
NFSHHVSPGF GGNFSPQIGP AAALSQHHPA PPPHPHFQHP HSQHQQHRRS PASPHPPPPF
PHRNAAFSQL PHLSNSLNKP PSPWGPASYQ SPSPSPGSST SWSPGGGYGS GGGWGGSQGR
DYRRGLNGGM TPINSISPLK KTFPNNHVAS QKYPRNSPAG FNPKSWMDDG VGRSDNIFPF
QERTRSFDSF NMNTLESSLI DIMRAEQDSL KGHSSLFPIE DGFPDDERGD QGLAGLGSPH
CFPHQNGERV ERYSRKVFVG GLPPDIDEDE ITASFRRFGH LFVDWPHKAE SKSYFPPKGY
AFLLFQDESS VQALIDACIE EDGKLYLCVS SPTIKDKPVQ IRPWNLNDSD FVMDGSQPLD
PRKTIFVGGV PRPLRAVELA MIMDRLYGGV CYAGIDTDPE LKYPKGAGRV AFSNQQSYIA
AISARFVQLQ HGEIDKRVEV KPYVLDDQLC DECQGTRCGG KFAPFFCANV TCLQYYCEYC
WAAIHSRAGR EFHKPLVKEG GDRPRHISFR WN
//
