ID I3JQ03_ORENI Unreviewed; 1071 AA.
AC I3JQ03;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Integrin subunit alpha 6 {ECO:0000313|Ensembl:ENSONIP00000010947.1};
GN Name=ITGA6 {ECO:0000313|Ensembl:ENSONIP00000010947.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010947.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000010947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_005452984.1; XM_005452927.3.
DR RefSeq; XP_019208362.1; XM_019352817.1.
DR AlphaFoldDB; I3JQ03; -.
DR Ensembl; ENSONIT00000010956.2; ENSONIP00000010947.1; ENSONIG00000008711.2.
DR GeneID; 100696272; -.
DR CTD; 503893; -.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000155353; -.
DR OrthoDB; 3816176at2759; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1013..1035
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 33..97
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 249..305
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 306..367
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 368..425
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 428..488
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 473..631
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 633..790
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 796..1000
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 101..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 118408 MW; DD7A2C544BF9833A CRC64;
MLLQGGRSAA HAALLFFVYG LEATFVLGFN LDTDHVLRKD GELGSLFGFS LAMHRQLNPD
KVMVLIGAPR ARSLENQKAN ITGGLYKCEV TQSNNCERIK FDDNADPRSE NKENQWMGVS
VKSQGPGGKI VTCAHRYQKR LNVNTPEETH HIPGRCYILS QDLTIDPQSS EDGGEWKFCD
GRPEGHAMFG TCQQGLAATF TNDYHYMVFG AVGAYNWKGI VRVEQNNSTF VDMGIFDDGP
YEVGNEKFRN PEFVPVPANS YLGFSLDSGH HITTRGKLTV VAGAPRANHS GAVVLFKQDI
VAGNLSTEYI LHGPGLGSCF GYDVAVVDLN NDGWQDIVIG APQFYMKGED IGGAVYVYIN
NAGVWEGNTP VRLIGTKDSM FGVAVENIGD INQDSYKDIA IGAPQEDSGT GKVYIYHGSA
QGIKTTPAQI LSGKDHNIRF FGYSLAGNMD LDGNSYPDLA VGSLSDSAII YRTRPVISLN
SVVKVSPNEI SLTNKTCGDR VCFTVMACFS YKANPASYNP KLTVSYDVEV DRAHRRGLTS
RAMFLNDSSS ELEYQFNGTL KLKEQNQQKC INLIARLKDN IKDKMRSIPV EVSADISTKQ
GESNNGLPPM NPILDATQPS KVISEVNFLK EGCGSDHICK SNLKMNYSLH YKEANKEEYP
PLEKSENDIP EFIVKSQRKD LAVLVTVSNM NGNDAYEAKL VGTFPNTMSY SGVRTDPKTM
ENPITCDANV NSSQAECELG NPFKRNSQVA FKVILSAAHL TLDTTEIEID LQLNTTSHQA
AIHVKVKCKV IIEWPLSVSG EANPTQVFFG GVVRGESAMK SEEEIGSSIN FTFTINNSWK
HLKPSFETSL NIYWPKVHKN GKWLLYLMSI DSEGPEKIHC SPKTEINPLN IAQQSSVSRT
KREIMKEERK TGGKTSSLKE KKRVFSCEDG MEKCVVFKCP LQGLDGTVIV LRSRLWNSTF
IEEYAPSSTL SVKATLEFDT QRENVILTNQ NMTVSVNVSP DNEGAKHQGG VPWWIILVAV
LIGVLILILL VYLLWKCGFF RRPSKDQYNA AYQKAEINIQ PSEKDKLSAE D
//
