ID I3JRH4_ORENI Unreviewed; 436 AA.
AC I3JRH4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Keratin, type I cytoskeletal 18 {ECO:0000313|Ensembl:ENSONIP00000011468.1};
GN Name=LOC100692359 {ECO:0000313|Ensembl:ENSONIP00000011468.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011468.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011468.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003449151.1; XM_003449103.4.
DR AlphaFoldDB; I3JRH4; -.
DR STRING; 8128.ENSONIP00000011468; -.
DR Ensembl; ENSONIT00000011477.2; ENSONIP00000011468.1; ENSONIG00000009120.2.
DR GeneID; 100692359; -.
DR KEGG; onl:100692359; -.
DR eggNOG; ENOG502QUS8; Eukaryota.
DR GeneTree; ENSGT00940000163961; -.
DR HOGENOM; CLU_012560_8_1_1; -.
DR InParanoid; I3JRH4; -.
DR OMA; KIRTDIQ; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF377; KERATIN, TYPE I CYTOSKELETAL 18-RELATED; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 81..393
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 85..119
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 191..236
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 291..385
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 436 AA; 48664 MW; 14B9A0E08DF24D8D CRC64;
MEPHFSRQSS QNFGVSSLAG PRSLRTETSY AHSVTGGAGG HGTKISSASY GSRIGSGLGG
GYNYQSLSSG STSGAMSIGN EKHAMQGLND RLANYLETVR NLEKANAVLE LKIREATESR
GHLEGRDYSK YYAIIEGLRA QIINMTKDTA QLTISLDNAR LASDDFRTKY EYELSMRQTV
EADVSRLRKI LDDTNVTRLH LESEIESLKE ELISLKKNHE REVDELRVQI AQAGVHVDVD
APKGQDLGRI MEEIRAKYEK IALQNQQELE AWHNSQITEI QFKVTESSAA LKEATGLMTE
SKRRHQALEI ELQSAHSLKA SLEAALHDIE RRYNLELEKY NEIILSLQEE LAQIRSNIQQ
NTNEYEALLN IKVKLEAEIA EYRRLLDGEG DLNLEDAVDL KKIQVVTVTQ TVVDGKVVSE
SKESKEIGST ENLALS
//
