ID I3JRT2_ORENI Unreviewed; 1016 AA.
AC I3JRT2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Integrin alpha-IIb {ECO:0000313|Ensembl:ENSONIP00000011577.2};
GN Name=LOC100704409 {ECO:0000313|Ensembl:ENSONIP00000011577.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011577.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011577.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_005469264.1; XM_005469207.3.
DR AlphaFoldDB; I3JRT2; -.
DR STRING; 8128.ENSONIP00000042113; -.
DR Ensembl; ENSONIT00000011586.2; ENSONIP00000011577.2; ENSONIG00000009206.2.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000160724; -.
DR HOGENOM; CLU_004111_4_0_1; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 19..1016
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5025710825"
FT TRANSMEM 964..986
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 21..82
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 293..357
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 358..417
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 420..481
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 469..592
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 613..749
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 755..955
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1016 AA; 111386 MW; 04F230ECEDD3EE8B CRC64;
MCVFRCVCVL LCVTLGVSLN LLDEVMFRGP TGSLFGFSVD FHTINNKSFV VIGAPKANTS
QSGVTEAGGV FLCPWSSRGR DCDIIDFDLT GDEVHRSSGL LFLSLKSQQW FGAAVRSVGS
THLLACAPLF HWNVQRGGVE SGITPVGNCL ILEHKTGNST PFSPCRGLMM EEDYKRMHNR
NDQRYCEVGF TADVTKDGRL VLGAPGSFFF QGQVITVGVD DIINSGKSDD PIKYVAGISQ
SDERGGYDVY HGYSVASGLL TGDSTPDYLV GVPNDRNTAG TVKIYDGRST GSLRVHHTFL
GAQVASYFGH SVAVADVNSD GLDDVLIGAP LFMDRVKEQL QERGQVVLYL QKKTFSSQPD
QSLIGLSLYG RFGSALAALG DLDMDGYQDV AVGAPWSGES GQGQVFIYLG NSNGLSGTPS
QVINSPLPSR TAFGFTLRSG ADIDGNGYPD LLVGAWAADR AFVYRSWTVI RSRVYVSLLP
DFLNPDVKLC HREKQSVSCF VIQMCVHLSG HRIPEETALE VELKLDRMKQ PMARRTLLLL
ANQPQETMEI TIKRKVGVAC VNRTAYLRSE EEVRDKLSPI FITAHISLLN TTQRALLHGQ
THTATQTRII LDCGADHVCV PELKLSAEPA SDTVFVGGDQ SVLLLVSAMN SGEGAYETEL
VVQIPEHTHF QSSQGVNGLV CMQRKENQTV VVTCDLGNPM RQGHKLQTGL LFSVGYLEEV
ESHITFNLRI RSKNSVNSSS NEVTVEVQVE AEATLQIRGG SSPQDIVLPL PDWQPAVHPG
SLEEVGPLVE HVYEVRNQGP SAVNARLTVE FPSTWRHHFL LYIFSNASEE SLSCWTLNTS
QIDPFKLAGN SSGVSAVSPS VQQEEPNSHR QTVHVNCSSG KAGCVRFVCD VTDLGRGFSA
VIRISARLWT NTLIETHQNY ELVSFATYDV ISTSSKVQPL LLDSGHTQTQ LRVLWRPDEK
TVPIGYIILS VICGLLLLCI LCFIFWKLGF FRRTRLPKDE DNDEDEQRLS EGHMTE
//
