ID I3JRX2_ORENI Unreviewed; 1199 AA.
AC I3JRX2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Tripartite motif containing 33 {ECO:0000313|Ensembl:ENSONIP00000011617.2};
GN Name=trim33 {ECO:0000313|Ensembl:ENSONIP00000011617.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011617.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011617.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005454162.1; XM_005454105.3.
DR AlphaFoldDB; I3JRX2; -.
DR Ensembl; ENSONIT00000011626.2; ENSONIP00000011617.2; ENSONIG00000009236.2.
DR GeneID; 100699306; -.
DR CTD; 51592; -.
DR GeneTree; ENSGT00940000156361; -.
DR HOGENOM; CLU_005817_0_1_1; -.
DR OrthoDB; 56754at2759; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05502; Bromo_tif1_like; 1.
DR CDD; cd16766; RING-HC_TIF1gamma; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45915:SF3; E3 UBIQUITIN-PROTEIN LIGASE TRIM33; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 165..225
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 252..299
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 314..355
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 977..1024
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1052..1132
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 384..433
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 23..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 130633 MW; 25E6C0D80CD9D26D CRC64;
MTSARTPNSR SYAGCAAVLR GRKMADNKGE EDMETSAKSD SVPSLQDTEP PETKNDNAVI
VIETNTKGDE ESESRENANE APTPSSEGGD VSSSSSSSSS GAAGAGGETN GSASPAGTSS
TNAEPTAAEA VGDAPVGGLA AEMSPPPAAS AATPVSTPIN LLDTCAVCKQ SLQSRDCEPK
LLPCLHSFCL KCIPQPDRQI SVQVPGPHGQ TDTHIVNVMR CSVCHQDYKQ SDIIDNYFVK
DTTEATSTSD EKAAQVCTSC EDNAGTIGFC VECGEWLCKT CVEAHQRVKI TKDHKIRTKE
DADAASESVS TSGQRPVFCP IHKQEPLKLF CETCDTLTCR DCQLLEHKEH RYQFLEEAFQ
NHKSIIETTM AKLQEKKNFV HYSVSQVQSR LKELNETHRK VEHEIKIAVF TLINEINKKG
KSLLQQLESV TKERSMRLVS QHKDTTQLAQ QIHHVLNFCH WAITTGSSTA LLYSKRLILY
QLRQLFKVRL EPAPQANGVV RFFCDPTFWA KNVVNLGNLV IEKPPSPAQP PGTVMVGGPP
ISPVQGHPSK HPGQINLAQL RLQHMQQAAY AHQKQQQQQQ QQQHQQQIQQ QMRIASRQAG
PPMVQQQPPR LISMQQIPRG PGGMNGGPGP PLYPSSHHMR LPGPSPGRMP TSQPRHNGQQ
YPPMMQPQLQ RQMSIESEMS HQRFRFLLQS GHSNPGHAGP FPVASLHNAN PTSPTSASMA
GAHAHRSPVN PAMGSIELIP SVTNPENLPC VPEIPPIQVE HAGTNYFEAI LHRSITASKD
QLNSQDPLPR QSPGSSGVPN FHTPARPSSN SSAGSRGSCS SAGRGGPGGG AAVEQVTVKQ
EPGTDDSYSC PASSLKTERG KDAERSACMM ISPENSPHPV LGAVSAGQDA LEALGERIKT
EPQSETPCSG LSDSSTAASS SSTTTMTSTT SSPTESSSTT TVAPLTNGNS NKGGETKRSE
ASTGTGNLEG KEDDPNEDWC AVCINGGDLL CCDRCPKVFH MKCHVPTIKI VPKGDFLCTF
CRSITNPEIE YCDESRKGKG EQDLSAEDQR KCERLLLYIF CHELSVGFRE PVPSSVPNYY
KIIKQPMDLK KVKKKLQLRN SQYYQSVQEF VSDIRLVFKN CAKYNEVGSE MAISGKAVSL
YFEEKLQEIF PGQSFPETAE PESPQEKEKE DDNTDDSEDD FIQPRRKRLK TDEKVVHIK
//
