ID   I3JS51_ORENI            Unreviewed;       351 AA.
AC   I3JS51;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Keratin, type I cytoskeletal 50 kDa {ECO:0000313|Ensembl:ENSONIP00000011696.2};
GN   Name=LOC100698206 {ECO:0000313|Ensembl:ENSONIP00000011696.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011696.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000011696.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JS51; -.
DR   Ensembl; ENSONIT00000011705.2; ENSONIP00000011696.2; ENSONIG00000009296.2.
DR   eggNOG; ENOG502QTM6; Eukaryota.
DR   GeneTree; ENSGT00950000182969; -.
DR   HOGENOM; CLU_012560_8_1_1; -.
DR   TreeFam; TF332742; -.
DR   Proteomes; UP000005207; Linkage group LG4.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF367; KERATIN 15-RELATED; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          9..320
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          13..54
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          112..157
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          218..305
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   351 AA;  40292 MW;  96BFB7B6BA8AE579 CRC64;
     DAIDISDNKK MAMQNLNDRL ASYLEKVRKL EAANAELELK IKEFLEKKTK VQGNDYSAYY
     ATISDLQEKI LDATHTNGSL YLTIDNAKLA ADDFKMKYEN ELSMRQSVEA DIAGLRKVLD
     ELTMTRSDLE MQIESLKEEL IHLKKNHEED LLTLRSQMSG QVNVEVDAAP QEDLTAVMAQ
     IRDHYENVAT KNRRELEAWF QTKSDELNKT VAESTEVLQS SRSEITELKR TLQSLEIELQ
     AQLSMKKSLE HTLAETQGRY ASMLAGYQGQ VTSLEEQLMQ LRADLERQRQ DYQMLLDIKT
     RLEMEIAEYR RLLDGELDSS SSSKTTTRKV VIVTRETTED GEVTTETQEM K
//