ID I3JT66_ORENI Unreviewed; 1511 AA.
AC I3JT66;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Adhesion G protein-coupled receptor L2 {ECO:0000313|Ensembl:ENSONIP00000012061.2};
GN Name=LOC100702950 {ECO:0000313|Ensembl:ENSONIP00000012061.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000012061.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000012061.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8128.ENSONIP00000012060; -.
DR Ensembl; ENSONIT00000012070.2; ENSONIP00000012061.2; ENSONIG00000009599.2.
DR GeneTree; ENSGT00940000156348; -.
DR HOGENOM; CLU_002753_1_0_1; -.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd16006; 7tmB2_Latrophilin-2; 1.
DR CDD; cd22845; Gal_Rha_Lectin_LPHN2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF61; ADHESION G PROTEIN-COUPLED RECEPTOR L2; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 868..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 967..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1006..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1073
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1079..1102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..133
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 141..400
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 491..547
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 862..1103
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 449..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1434..1449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 142..324
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1511 AA; 168271 MW; 5A4F5A8689A214C9 CRC64;
MDYITLLSAG ILPFFPLLLL LLLLLLFFTD RAALPFGLVR RELSCEGYAI DLRCPGSDVI
MIETANYGRT DDKICDADPF QMENVQCYLP DAYKIISQRC NNRTQCVVVT GSDVFPDPCP
GTYKYLEVQY ECVPYSKYLF ICPGTLKSIG AATFLFEGEQ QAGSWCKDPL QAGDKIFFMP
WTPYRTDTLI EYASLEDLKN GRQTTTYKLP HRVDGTGFVA YDGAIFFNKE RTRNIVKFDL
RTRIKSGEAI VNNANYHDTS PYRWGGKTDI DLAVDERGLW VIYATEQNNG RIVVSQLNPY
TLRFEATWET AYDKRSASNA FMVCGVLHVV RSTYEENESE ASRSQIDYIY NTKLSQGEYT
DILFPNQYQY ITAVDYNPRD NQLYVWNNFY ILRYDLDFGP MFMSRALTAS LLSPSLSLSV
VPTTEDASVS SAMPKTTTIT TTTAVSTVKG RGDTTVAGAD PRDGRDPFED SRGLSTAEPT
IPELPPTPRR FCEVTRRRAI DWPQTHTGTT VERPCPKGTR GIASFLCTMA GTWCSKGPDL
SNCTSHWVTQ VAQKIRSGEN AANLANELAR HTQGPVFAGD VSSSVRLMEQ LVDILDAQLQ
ELKPNEKDSA GRTDKFVLSP WIQAIVDTVD NLLRPEALKS WKDMNSTEQT HAATMLLDTL
EEGAFVLAEN LIEPAIVKVP AENILLEVCV LSTDGQVQDF RFPQTSKSGM TLQLSSNTVK
VNSKNGVAKL VFVLYKHLGQ FLSTENATLR GMGDLNKHNL SLTVNSHILS ASITKESSRV
FVADPVIFTL EHLDKEHYYN PNCSFWNYSE RSMMGYWSTQ GCKLLETNKS HTTCSCSHLT
NFAILMAHRG NVRDGSVHEV LLTVITRMGI AVSLVCLAIS LFTFCFFRGL QSDRNTIHKN
LCLNLFIGEL LFLVGINMTE PKLVCSIIAG VLHFCFLAAF VWMCLEGVQL YLMLVEVFES
EFSRRKYYYM SGYLIPAVVV GISAAIDYRS YGTQRACWLR VDNHFIWSFI GPVTFIIVVN
VIFLVVTMYK MVKHSTSMKP DSSRLGGIRS WVLGAFALLC LLGLTWSFGL FFLNESSIVM
AYLFTIFNTL QGMFIFIFHC LLQKKVRKEY SKCFRQSQCC GALPSEGSHS SAKTATSRST
ARYSSATQSR IRRMWNDTVR KQSESSFISG DINSTSTLNQ GMTGNYLLTN PLLRTHDTNP
YNNLLAETVV CNTPSPPAFH SPGSLSNSRD ISAMDTLPLN GNFNNSYSLR DDDYEAVGVR
APGDLGGLNL DDATFEKLII SEIVHNNLRP RGAPKGRDAP RERDRVLPPQ TRVTVDRGGG
GSGSEDDAIV ADHADASSPQ RGSGRGGHAT LELLLHPHHK EVLEAPLLPQ RTHSLLYSSQ
KAPRCLEGQS SHGSETVTAE EDMGSHSPSN NRDSLYTSMP NLRDSPSPSA SPYPPEEEEE
EEEELSPSPQ SESEDAYHKS MPELGDAPQP LSYYHINRGT SDGCIIPPNN EDCAHDGEAP
ADGQMQLITS L
//
