ID   I3JU39_ORENI            Unreviewed;       510 AA.
AC   I3JU39;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=PAT complex subunit CCDC47 {ECO:0000256|ARBA:ARBA00034875};
DE   AltName: Full=Coiled-coil domain-containing protein 47 {ECO:0000256|ARBA:ARBA00034902};
GN   Name=ccdc47 {ECO:0000313|Ensembl:ENSONIP00000012384.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000012384.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000012384.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004115}. Rough endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00034697}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00034697}.
CC   -!- SIMILARITY: Belongs to the CCDC47 family.
CC       {ECO:0000256|ARBA:ARBA00034746}.
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DR   RefSeq; XP_003442455.1; XM_003442407.4.
DR   RefSeq; XP_013125233.1; XM_013269779.2.
DR   AlphaFoldDB; I3JU39; -.
DR   STRING; 8128.ENSONIP00000049579; -.
DR   Ensembl; ENSONIT00000012393.2; ENSONIP00000012384.1; ENSONIG00000009857.2.
DR   GeneID; 100703056; -.
DR   KEGG; onl:100703056; -.
DR   CTD; 57003; -.
DR   eggNOG; KOG2357; Eukaryota.
DR   GeneTree; ENSGT00390000013997; -.
DR   HOGENOM; CLU_033196_1_0_1; -.
DR   OrthoDB; 5252467at2759; -.
DR   TreeFam; TF314902; -.
DR   Proteomes; UP000005207; Linkage group LG4.
DR   GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:InterPro.
DR   InterPro; IPR012879; CCDC47.
DR   PANTHER; PTHR12883; ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED; 1.
DR   PANTHER; PTHR12883:SF0; PAT COMPLEX SUBUNIT CCDC47; 1.
DR   Pfam; PF07946; CCDC47; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          71..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..116
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        444..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  58522 MW;  3B044BDD602B28EA CRC64;
     MLFNLHEHSF YRHRSTSGPT MRSLYLLLIP ALLLLLAIPV SRGRYNDDFD DGEDLADFDD
     NDFAEFEDMT DDSAAEAETA PPPRASPSLQ PDEDEDEDEA TVELEDGQDG FEDPDTQDQD
     IYSKYDQEEF EGIGDMEKTG QSMKDPLIIH TVPAHLQNSW ESYYMEILMV TGLLAYIMNY
     IIGKNKNSRL AQAWFNSHRE LLESNFALVG DDGTSKEAVS TGKLNQENEH IYNLWCSGRV
     CCEGMLIQLK FLKRQDLLNV LARMMRPACD QVQVKVTLND EDMDTFVFAV GTKKAMARLQ
     KEMQDLSEFC GDKPKSGAKY GLPESLAILS EMGEVTDGVM DNKMVHYITN HADKIESIHF
     SDQFSGPKVM QEEGQPLKLP ETKKTLLFTF NVPGMGNTSP KDMDALLPLM NMVIYSIDKV
     KKLRLNREGK QKADKNRARV EENFLKQTHA QRQEAAQTRR EEKKRAEKER IMNEEDPERQ
     RRLEEAAQRR EQKKIEKKQM KMKQIKVKAM
//