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Database: UniProt
Entry: I3JUM4_ORENI
LinkDB: I3JUM4_ORENI
Original site: I3JUM4_ORENI 
ID   I3JUM4_ORENI            Unreviewed;      1003 AA.
AC   I3JUM4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 78.
DE   SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 {ECO:0000313|Ensembl:ENSONIP00000012569.2};
GN   Name=smarca5 {ECO:0000313|Ensembl:ENSONIP00000012569.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000012569.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000012569.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC       {ECO:0000256|ARBA:ARBA00009687}.
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DR   AlphaFoldDB; I3JUM4; -.
DR   STRING; 8128.ENSONIP00000034506; -.
DR   Ensembl; ENSONIT00000012579.2; ENSONIP00000012569.2; ENSONIG00000009993.2.
DR   eggNOG; KOG0385; Eukaryota.
DR   GeneTree; ENSGT00940000157297; -.
DR   HOGENOM; CLU_000315_0_3_1; -.
DR   TreeFam; TF300674; -.
DR   Proteomes; UP000005207; Linkage group LG6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR   CDD; cd00167; SANT; 1.
DR   CDD; cd18793; SF2_C_SNF; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR   Gene3D; 1.20.5.1190; iswi atpase; 1.
DR   Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR015194; ISWI_HAND-dom.
DR   InterPro; IPR036306; ISWI_HAND-dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   InterPro; IPR015195; SLIDE.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR   PANTHER; PTHR45623:SF49; ISW-1; 1.
DR   Pfam; PF09110; HAND; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF09111; SLIDE; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          142..307
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          437..588
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          790..842
FT                   /note="SANT"
FT                   /evidence="ECO:0000259|PROSITE:PS51293"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          58..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..1003
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          763..790
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        9..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        966..996
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1003 AA;  117036 MW;  F2B3980302CE911F CRC64;
     HSLRRNAGAD GQDASSSSSS SKTKDSTPGY EEKVQTDRTN RFEYLLKQTE LFAHFIQPAA
     QKTPTSPLKM KPGRPRIKKD EKQNLLSAGD NRHRRTEQEE DEELLNESTK TTNVCTRFDE
     SPSYVKTGKM RDYQVRGLNW LISLYENGIN GILADEMGLG KTLQTIALLG YMKHYRNIPG
     PHMVLVPKST LYNWMNEFKR WVPSLRAVCL IGDRDERTAL IRDVLLPGEW DVCVTSYEML
     IIEKAVFKKF NWRYLVIDEA HRIKNEKSKL SEIVREFKTT NRLLLTGTPL QNNLHELWAL
     LNFLLPDVFN SSEDFDSWFD TNNCLGDQKL VERLHTVLRP FLLRRIKADV EKTLLPKKEI
     KIYVGLSKMQ REWYTKILMK DIDILNSAGK MDKMRLLNVL MQLRKCCNHP YLFDGAEPGP
     PYTTDIHLAV NSGKMVVLDK LLPKLKEQGS RVLIFSQMTR MLDILEDYCM WRNYGYCRLD
     GQTPHEERQI SINAFNEPNS SKFIFMLSTR AGGLGINLAT ADVVILYDSD WNPQVDLQAM
     DRAHRIGQQK QVRVFRFITE NTVEERIVER AEMKLRLDSI VIQQGRLVDP SANKLGKDEM
     LSIIRHGATH VFASKESEIT DDDIDAILER GERKTMEMKE RMSSLGESSL RNFTMDTENT
     SVYTFEGEDY REKKKVITNW IEPPKRERKA NYAVDAYFRE ALRVSEPKAP KAPRPPKQPN
     VQDFQFFPPR LFELLEKEIL FYRKTIGYKV PRNPDIPNSA QVQKEEQAKI DEAEALTEEE
     LEEKESLLQQ GFTIWNKRDF NQFIKANEKW GRDDIENIAR EVEGKTPEEV MEYSAVFWER
     CNELQDIEKI MAQIERGEAR IQRRISIKKA LDSKIGRYKA PFHQLRISYG TNKGKNYTEE
     EDRFLICMLH KLGFDKESVY DELRQCIRNS PQFRFDWFLK SRTAMELQRR CNTLITLIER
     ENMELEEREK AEKKKRGPKT GSAQKRKSEG TPDGRGRRKK LKL
//
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