ID I3JWW7_ORENI Unreviewed; 486 AA.
AC I3JWW7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=glycerol kinase {ECO:0000256|ARBA:ARBA00012099};
DE EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
GN Name=gk5 {ECO:0000313|Ensembl:ENSONIP00000013362.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013362.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013362.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005190}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
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DR AlphaFoldDB; I3JWW7; -.
DR STRING; 8128.ENSONIP00000056794; -.
DR Ensembl; ENSONIT00000013372.2; ENSONIP00000013362.2; ENSONIG00000010628.2.
DR eggNOG; KOG2517; Eukaryota.
DR GeneTree; ENSGT01000000214434; -.
DR HOGENOM; CLU_009281_2_3_1; -.
DR TreeFam; TF321504; -.
DR UniPathway; UPA00618; UER00672.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR PANTHER; PTHR10196:SF68; GLYCEROL KINASE 5-RELATED; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 2.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|RuleBase:RU003733};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transferase {ECO:0000256|RuleBase:RU003733}.
FT DOMAIN 12..244
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 259..426
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 486 AA; 54161 MW; 97891311FF1E22AA CRC64;
LPCANGFKKE SYILSVDVGT TSIRCHVYDK EAKIRGSCST KVVLLYPEVG HVEMDPDDLW
KGFISVVKGA VQDAGIQMHQ VEALGISTQR GTFTTWDRRT GVPFHNFISW QDQRAADLVK
SWNRSCTMKA IHGAMKVLYF VTRQKRLLAA SLVVFSTQHV TFRLVWVLTH YTQVHEAIDE
GNCCFGTIDS WLLFKLTKGH LHATDYSNAS STGIFDSYQM CWSGFLSSLV SLPLSIFPKM
ADQQAAMFGE CCFDVGDVKI TMGTGTFMDI NTGSLYPLVG WKIGSEVVYL AEGNAADTGT
AIKWAQKLEL FSDVRETSAM AYSVSDSDGV CFVPSFSACA SLMGLKPSTT KSHLVRAILE
SVAFRNKQLY ETMLRETRIP ITKIRVDGGV SSNDFVMQLT SDLFGKKISR PQHHEMSCLG
AAFVAGLEVG FWRTREELKK LQSADDEFSP QCADKECTGS PNGEYVPILQ SWERALRRSM
NWYNKP
//
