ID I3K047_ORENI Unreviewed; 764 AA.
AC I3K047;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=AE binding protein 1 {ECO:0000313|Ensembl:ENSONIP00000014492.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014492.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000014492.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
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DR AlphaFoldDB; I3K047; -.
DR STRING; 8128.ENSONIP00000058672; -.
DR Ensembl; ENSONIT00000014503.2; ENSONIP00000014492.2; ENSONIG00000011513.2.
DR eggNOG; KOG2649; Eukaryota.
DR GeneTree; ENSGT00940000158323; -.
DR HOGENOM; CLU_006722_2_0_1; -.
DR TreeFam; TF315592; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11532:SF48; ADIPOCYTE ENHANCER-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..203
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
SQ SEQUENCE 764 AA; 86998 MW; A196FEEDEFC54E83 CRC64;
EEEERRKQIS VPAEPKSKRV SLFCSLCLSA KFVTQIFLVC ALISLPECPP LGLESHRVED
DQLLASSQSH HGFSAQRGRL NMQGSDNDED LYGGAWCAES EERDHWFQVD ARREVEFTGV
ITQGRNSELH EDFVSSYFVA FSNDSSDWTL LHDGYAEWLF YGNVDKETPV MSQFATPVVA
RYIRILPQSW NGSLCLRAEI LACQLPSYEN EVNPSDDLDF RHHNYKEMRQ MMKVINEECP
NITRIYNIGK SYQGLKMYAM EISDNPGEHE PGEPEFRYTA GLHGNEALGR ELLLLLMQFL
CKEYNDDNPR VRRLVDGVRI HLVPSLNPDA YELAYEMGSE MGNWALGHWT EEGYDIFQNF
PDLNSILWGA EDRGWVPRIV PNHHIPLPEN FFNGSLAVET KAVISWMDRN PFVLGANLQG
GEKLVTYPFD MQRPPRQNEG ALRETPDDAM FRWLAMSYAH SHLTMTETYR GSCHGDDITG
GQGITNRASW KPVVGSMNDF SYLHTNCFEL SIFLGCDKFP HESELPLEWE NNREALLSFI
EQVHRGIKGI VRDVDGNPLP NATISVEGIR HDVKTAVGGD YWRLLNPGEY KVTAKADGYT
PQTRLCMVGY DSGATPCSFT LTKSNWDRIK HIMALHGKRP IRLITKVNVV KTTAASTVAA
PSIDTEPENP ANTHNIARRR RLRLMRLRRL RLQRLRAGLR TTPATTVTTT TTTASTTLPP
ETKRTTSWYD SWFPVDEWST ENPFDSVVFE AVPTQDYPFE YTID
//