ID   I3K0D5_ORENI            Unreviewed;       619 AA.
AC   I3K0D5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Carnitine O-acetyltransferase a {ECO:0000313|Ensembl:ENSONIP00000014580.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014580.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000014580.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232}.
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DR   AlphaFoldDB; I3K0D5; -.
DR   STRING; 8128.ENSONIP00000014580; -.
DR   Ensembl; ENSONIT00000014591.2; ENSONIP00000014580.2; ENSONIG00000011577.2.
DR   eggNOG; KOG3717; Eukaryota.
DR   GeneTree; ENSGT01060000248556; -.
DR   HOGENOM; CLU_013513_5_0_1; -.
DR   InParanoid; I3K0D5; -.
DR   OMA; YNTHVHT; -.
DR   TreeFam; TF313836; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589:SF50; CARNITINE O-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          49..597
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        332
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   619 AA;  70045 MW;  5E82F52BEB45EC2E CRC64;
     MLTILNRIIV NVGMMNSYGL VKSCRLVNSA SDTLMGGRYL NHQKGLPRLP VPPLRETCER
     YLSCLEPIVT VDELKHTKQL MKEFLKEGGD GEKLQRSLER KACTTDNWLA DYGIQINYLD
     SRESLLIYNT HVHTWKNDTP SSICSETLPV QYMRGEPLCM MQYFRALSSC RVPGRKTDSL
     VFHAKNSNGP RHITVAQNSQ FFTVEVYHSD GTPITADQLC VQLQRICNSS LETNAEHVGI
     LTTLRRDAWY KYYNKLVQDP SNKKSVSAIE RSICVLCLDK AIPRTYEKYS GFEPLQVLHG
     GGSQWNSANR WFDKSLQFIV GEDGTCGFNM LHAIIDGTPC MALSDYITSS MKKPQMMESP
     VALLPMPQKL HFNITPDIKT AIEEAKQSID KHAQDLDLRV LVFNHFGKKI PKAHQISPDA
     FIQMAIQLAY YRIHQQCCAS YEAASMRLFK KGRLGVILST SSASAAFVKS FDDPKKQNSD
     KRNLLENAIK VHTWNTNMEI RGRTTFGHFL ALKVQAIENS IPMPDIYTDT SLDKAFNFLL
     STSQVSFKAS CLACAVPEKL NVYDFCYSVT SDDFTFVVSA WKSCKENNVV RLIQTLEDTL
     LDMKMLLEET KLESDAKLS
//