ID   I3K0D8_ORENI            Unreviewed;       600 AA.
AC   I3K0D8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Carnitine O-acetyltransferase a {ECO:0000313|Ensembl:ENSONIP00000014583.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014583.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000014583.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232}.
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DR   AlphaFoldDB; I3K0D8; -.
DR   STRING; 8128.ENSONIP00000014583; -.
DR   Ensembl; ENSONIT00000014594.2; ENSONIP00000014583.2; ENSONIG00000011580.2.
DR   eggNOG; KOG3717; Eukaryota.
DR   GeneTree; ENSGT01060000248556; -.
DR   HOGENOM; CLU_013513_5_0_1; -.
DR   InParanoid; I3K0D8; -.
DR   OMA; YECHGKD; -.
DR   TreeFam; TF313836; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589:SF50; CARNITINE O-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          39..590
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        343
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   600 AA;  67810 MW;  A48F493818AAE1BE CRC64;
     MGMVNPCALV SSCHLMKTVS RTWVNGRCLT YQQALPTQPV PTLQHTCERY LILLEPFVEV
     DELKRTKQLV QEFLKPGGVG EKLQKGLERK AHNTDNWLTD YMVQTDYLDN RLPVVAYSNN
     SGSFPRMDFR DEEGQIRCAA KVIRAILDSK TMTDNEALPA DYLGGKPLCM KQYSQMLSSC
     RIPGLETDSV VFHGKTSYPS RCITLAYNSQ FFMLEVYNSD GSPLTVHQLC VQLERICSSS
     LETSTEPVGI LTSLNRDSWS KCYDRLIQDK TNKEALSAIQ RSICVVCLDK AMPQVPDDMY
     TRCNVLQMMH GGGSQWNSAN RWFDKSLQFI IGEDGAFGNN VSHSCLDEIM ESSTVPLPTP
     QKLHFNITAD IKKAIEEAKR SIDKIVQDLD FSILSFNHYG KNFLKANKMS PDAFIQMAIQ
     LAYYRVHRQH CASYEAASMR LFRQGRVGEI PSTSSASVAF VMAFNDPNKK NTEKVDLLRK
     AIEVHKWNTN MEISGQTVFG HFLGLQHQAT EKNIPMPDIF TDASFDKVFD YRLATSQVPS
     KSGCLPCAGP YQYKTYDICY TLLKDDMTFV VSAFKTNTEN NSEELKKAVE DALLDMRTIL
//