ID I3K0G7_ORENI Unreviewed; 883 AA.
AC I3K0G7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Gamma-aminobutyric acid (GABA) B receptor, 1b {ECO:0000313|Ensembl:ENSONIP00000014612.2};
GN Name=GABBR1 {ECO:0000313|Ensembl:ENSONIP00000014612.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014612.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000014612.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR AlphaFoldDB; I3K0G7; -.
DR STRING; 8128.ENSONIP00000014612; -.
DR Ensembl; ENSONIT00000014623.2; ENSONIP00000014612.2; ENSONIG00000011603.2.
DR eggNOG; KOG1055; Eukaryota.
DR GeneTree; ENSGT00940000157642; -.
DR HOGENOM; CLU_005240_2_0_1; -.
DR InParanoid; I3K0G7; -.
DR OMA; HSHPFAN; -.
DR TreeFam; TF313965; -.
DR Proteomes; UP000005207; Linkage group LG22.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0035095; P:behavioral response to nicotine; IEA:Ensembl.
DR CDD; cd15291; 7tmC_GABA-B-R1; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR002456; GPCR_3_GABA_rcpt_B1.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF76; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 459..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 466..744
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 737..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..833
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 99914 MW; 77ADC612F924A3D4 CRC64;
MTRLCQNLPR RPVSRYSLIF ILTVLACSCP ALGKKKLYIG ALFPMSGGWP GGQACLPAAQ
MALDLVNNRT DILPDYELEL IYYDSMCDPG EATKLLYDLL YTEPIKIVLM PGCSSVSTLV
AEAARMWNLI VLSYGSSSPA LSNRQRFPTF FRTHPSATLH NPTRVQLFQK WKWTKIATIQ
QTTEVFTSTL DDLEERVKEA GIEISVRQSF LTDPAVAVKN LKRQDARIIV GLFYETEARK
VFCEVYKEKL YGKKYVWFLI GWYADNWFKI KDPSINCTVE QMTEAVEGHV TTEIVMLNPE
TVRGASNLTS QEFLAQLMSK LGGKNPEETG GFQEAPLAYD AVWALALALN KTVGPLRAKG
HHLEDFNYNN RDITAEIYRA MNTSSFEGVS GHVVFDAQGS RMAWTLIEQL QGGSYKKIGY
YDSTKGNLSW YGNDKWIGSG PPADQTVVIE EFRYLSQKLF VSVSVFAGLG ILLGIVCLTF
NIYNSNVRYI QNSQPYLNNM TAVGCMMSLA AVFPLGIDGL HVHRKQFPVI CQFRLWLLGL
GFSLAYGSMF TKIWWVHTVF TKKDEKKDKK KHLEPWKLYA TVGVLLGIDI LSLMIWQIVD
PLHITVEKFT REAPKGDLDV LIQPLLEHCN SEKMNTWLGV VYGYKGLLLL LGIFLAYETK
SISTEKINDH RAVGMAIYNV AVLCMITAPV TMILSSQQDA SFAFASLAIV FSVYITLVVL
FVPKMRRLIT RGEWQSDTQE TMKTGSSTNN NDEEKSRQLE RENKELQKII QEKEERVSEL
RNQLSERQAL RSRRRASTIT YQNHSPPPFS ITQSDPRSLA PPPGYPAPAS DPHPVPQSFA
NSSSLYQSDS KISRNKCHTS RLQLLYKSLV YHYYYNLKTV ERL
//
