ID I3K0X7_ORENI Unreviewed; 2938 AA.
AC I3K0X7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Crystallin beta-gamma domain containing 1a {ECO:0000313|Ensembl:ENSONIP00000014772.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014772.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000014772.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
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DR STRING; 8128.ENSONIP00000014772; -.
DR Ensembl; ENSONIT00000014784.2; ENSONIP00000014772.2; ENSONIG00000011731.2.
DR eggNOG; ENOG502QUA4; Eukaryota.
DR GeneTree; ENSGT00940000155695; -.
DR HOGENOM; CLU_002147_2_1_1; -.
DR InParanoid; I3K0X7; -.
DR OMA; DWDPHSE; -.
DR TreeFam; TF331078; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 6.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11818:SF131; ABSENT IN MELANOMA 1 PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR Pfam; PF00030; Crystall; 6.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 6.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 8.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2237..2276
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 2277..2309
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 2383..2425
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 2437..2488
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 2489..2531
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 2580..2622
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 2669..2713
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 2760..2801
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT REGION 1..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1817..1837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1858..1894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2057..2141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1547..1570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1638..1657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1704..1718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1719..1739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1781..1797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1858..1879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1986..2008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2057..2088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2106..2137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2938 AA; 320446 MW; 004AE3D87ED97D0B CRC64;
MYKKKPAAAE PAARGQAANQ AAPQKRVVRG AAESRHTTAS GTKTPTSAAG NKAKNVLTKA
KGSTEGTKVE TSSDNPTQRD GAVIMLPAFK DQSASAPSGA AGSKSKIPKR STSDADVKSP
VTPDKTSTPD TSGPKLQKQP RTKETLKSPT TAARPGRKPS FEENRGKSVS GNISPVKTRT
GTKLSKDKSD EDFESVNLLN DVENEERKSG HPPHRESPDV KKTQQQNDVE SSPKSRLPVS
SPTRKKVDIT YKRVSSGQMD SDRPKTVQKT SPEQKDATAD ESPGSETPPP LPESPKKAGI
VPPMKPPKNF SKRIHVESDT PTSSISPLPT KQEKTVSSRI FKWNENIKQH QKMPAKDSPE
TSSSVSKLPT RGQRSSNKLK PRQRSQSGNS EDSNHNTSTE TDVKAPESIT ANERDSEDIF
KFKSEGEECF IKHTDETKVK EKEIGTSTAT EDISNIQRLQ NSDTVITKSV PDTGAEVQSS
CEIDKAIPSQ VTDGGRAENL SAVQNKNTTR EPKSPSLKTL KLTGNVKLGL SQDKNTAPRI
HDTKQAPEDE TDMPSKPAEG DSVQREIRGR IPVNKINAFT SKQEINSSSI PTKLISKDDS
DQSKPANTEQ QKDLSREDQF TNERDTSLTL NRALAKDVEV EEKSKEEGGR KPAERLGIQT
EAVTVGELSK NVENQLHKEA LLLAGGSEER GSKPNETLSD TAVESTESQN GCKEVLKGIT
TERAITNSEK SAHLSSEDRG SSAESKEETQ TGVTNALKEQ TREEQAILHE TTKQQPEMPL
KENTESSAEK TKASEVKNES KLLLTKDEEV GDEDTSLDDK RDRGVKGRRT PEIRDVNTFD
AEADKEKKTL LNVTQENKKA VAAKDRGEDI TTKANLNQAL AEVKASKKTS EKHILKSDAT
KEVKGARTEA TEDLSINSLV SGTEAANADI KANIQEDQKS IIVGDLNKDI TNAVKHPDDK
LDQKPEMVKT GGQEKTVESQ NMDITQDQTS LSTEDTKERI DTNELSVDSP GNDAVTADNE
LQGESITKPA QEKSVQEKTV ESQEKDIIQE LISVNTSTEG TREKTEVSDS SVESLEKEMG
DMNANSVSKQ QTDQDGNATK PEMNQSTGSK KENKDGNKSS LKSGLKKRVG IVQPESLVEA
ESQIQDLKVV CDEEPKDKNE TKDSSAESLV KKPRTLGTNS DAGIQQDLTS LKVEVDNLEE
LSESKLHESE QKPEMVRAEV QEKITEIQNT DATQELTSGG SSTDDTNEKT EVKVVSTANA
DNDVSKQQVQ ALVTLNNQDG SITKQESNKS AESTSPTFVL KAESPQEAAE SQNQGIKDAD
GAKEKAETKD SSAESSVSET ETLQTHIDAG PVEEASSTTP EIQDHKVKQK PETVRAEGQQ
KTTEIQNTDA TQEPASGGSS TEGANEKTEV KLSSSPNANN DVSKQQVEAP VTLNNQDGSI
TKQGSDRSAE STSPTSALKS ESPQEVTESQ NQDLKDADGA KEKAETKNSS AESSVNKTEA
LQTHIDAGIQ QDLKPVKAEV QDQEELTESK LNEFEQKQEA VRAEVQEKTT EIQNTDATQE
LTSGASSTED ANEKTEVKVV STGNADNDVS KQQVQAPVTL NNQDGSITKQ GSDKSAESTS
PTSALKAGSL QEAAETQNQD LKDADGVKEK AETKDSSAES SVNEMATKVS DKQNGDITKP
ELNKSTESKC PQPGLQQGPE TVKTESTDDV ESKISSAETL ENEKANNEIS SQKDQKSTPV
KVVQIKKPET ITEPHTAPGT NQEQKSKAVA TKDLKKATKD PELSVTSSVS TAGKAAGKQE
QKNLIKEVVG VDEKLKASEM NAKKESPTVG SSEVFLKDKE TKEKRETDFL GSAFKKGLQT
AEKSSTSSQS LQSNADVPSG WLDVESHQKK RRVHKRRFNT SASVDDPLDD TSDFDDFIRN
IKEGGMPFAL PPKKHVHKKS PPPHFVLPAI KEDHFEKTFD PEEFQFGLRK NGRTFIDLLP
TTILKQKGNQ RNGQTLEKNA TPTPEQQAKT LDEVEGKSGL QEGAKAKAGK EGQDNGEEPV
KLTSRLNKIS ILSSLLTTRS TRKSTEEASS ASNSTPSSDQ QQGMPSLRNV EAADSPKPEA
TADNVGGTGV DQSPVTGGGT GRVSESVFSS SSPPPLVLPS FSDIKLPEHL EKLLKKNKKE
TETSTAQTIQ TNQNTKETIA MDQDLIAGLT KVDLNLKSPE ELPPITNYIQ QRPPNGFQKT
TSKPKIPAVR GFHKRPGKII IHEHAQFGGE AFELYSDVED ATTMKLSPII SVRVIRGCWL
LYEKPGFQGR IIALEEGPTD GIVNVWAEEE SPATLGEMGE PIPTAPVVIG SIRLAVRDYS
MPQIDLFSEV NGLGRMASYS DDTVEVSSYG IPQTTGSIKV HSGVWLVYTD PGFAGFVGVL
EVGEYPCPEA WGFPEPFVGS LRPLRMGVIK VERPNEVKAL LYEKPNFDGE CLEVHSDIYN
VQEPDEESDE PAVNKKTLCA VGSLKILGGL WVGYQEADFE GQQYILEEGE YPHCSDWGGS
EDGLQSLRPV ISDFVSPHVK LFSEQDFSER GLSTNLLVPV VNLEETGHGA KTQSVDVSGG
VWVAFEKPGF SGELYVLEKG MYANPEDWGA QNFRIASIQP VFHDSMGTTK FKVQLYSEEH
FQGRLVSLED SAAALDEDFT PRSCKVLAGS WVAYEGSQFT ENMYILEEGE YPSTEAMGFL
SSDWSFRSIQ TAGHEFSLPS IALFTKVGCR GRRVVLTHEA VNLHQAGLDT RIRSLVVEGG
MWVLYEGSNY RGRQVILQPS QVADLFQRSG FQRVGSLRPL LQKPMYFRLR NRETGCMMSL
TGTLEDIKLM RVQAVEETGG EEQVWLYRDG YLTCKVVEDC FLESSGSVMM AGSRICVSPE
RGKDNQLWNI SPDGVVHSNL KPDLILEVKG GHQYDKNQVI LNTFDERKLN QRWSLELL
//
