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Database: UniProt
Entry: I3K1K5_ORENI
LinkDB: I3K1K5_ORENI
Original site: I3K1K5_ORENI 
ID   I3K1K5_ORENI            Unreviewed;      1955 AA.
AC   I3K1K5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A (1 of many) {ECO:0000313|Ensembl:ENSONIP00000015000};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015000, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000015000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000015000}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000015000}.
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DR   EMBL; AERX01019392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01019393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000015000; -.
DR   Ensembl; ENSONIT00000015013; ENSONIP00000015000; ENSONIG00000011915.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; YMIDEDH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    227    248       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    348    367       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    724    742       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    754    772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    834    862       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    921    947       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1171   1189       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1229       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1241   1261       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1287   1313       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1410   1436       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1495   1513       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1525   1543       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1555   1575       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1612   1640       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1715   1738       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      495    672       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      724    951       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      961   1164       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1169   1444       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1494   1748       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      411    449       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1955 AA;  222505 MW;  DE47658E68BA8D34 CRC64;
     MAAPLLAPPG PDSFKKFTPE SLAVLEQRIQ EEKNKKPPKQ DSSYRDDDDE NKPKPNSDLE
     AGKSLPYIYG DIPKGAMFTS ISKYSKPYLT KQTFIVLNKG KTIFRFSATP ALYLISPFNP
     VRRLAIKILI HSLFSMIIMC TILTNCIFMT FSDPPEWSKQ VEYTFTGIYT FESLVKITAR
     GFCIDGFTFL RDPWNWLDFM VISMAYITEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRHK CVIWPINTNE SYLANGSKGF
     DWDEYITNDT NFYFLPGQLD ALLCGNSSDS GRCPEGYTCM KAGRNPNYGY TSFDSFGWAF
     LALFRLMTQD FWENLYMLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA
     TMEEAAQKEE EFKAMLEQLK KQQEDAQTAA MATSAGTVSE DAVEDDGGGR LSCSSSEMSK
     LSSKSAKERR NRKKKWRQKE QEKEKGDSEK FVKSESDDGS KRSRFRFPDN RLGRKSSIMN
     QSLLSIPGSP FLSRHNSKSS IFSFKGRSKD VGSENEFADD EHSTVEECEE RRGSLFSPYR
     RSSYTGFHGK RNSTVDCNGV VSLIGPGPGG RLLPEPTTEV EVKKKLSGSL MVSVDQLNTS
     FGRKERANSV MSVITNTLVE ELEESQRKCP PCWYKFANTF LIWECCPMWI KIKEIVNLIV
     MDPFVDLAIT ICIVLNTLFM AMEHYPMTSD FEDMLSVGNL VFTGIFAGEM LFKLVAMDPY
     YYFQEAWNCF DGFIVTLSLV ELALADVEGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN
     SVGALGNLTL VLAIIVFIFA VVGMQLFGKN YKDCVCKISA ECELPRWHMN DFFHSFLIVF
     RVLCGEWIET MWDCMEVAGQ AMCLIVFMMV MVIGNLVVLN LFLALLLSSF SADNLAATDD
     DGEPNNLQIS VMRIKKGIAW IKAKMRLLVA SLLRKPPMED EQKPLEDMYD KKLNCIANHT
     GVDINRDLDY AKNGNGTTSG IGSSVGKYMI DEDHMSFIHN PNLTVCVPIA VGESDFENLN
     TEDFSSESDN ENSKEKLDDT SSSEGSTIDI KPDVEEVVVV ETVEEYMEPE PCWTDACVAK
     YKCCDVDITM GWGKSWWFLR KTCYLIVEHN WFETLIIFMI LLSSGALAFE DVYIEQRKTV
     RIILEYADRV FTYIFILEML LKWVAYGFVK YFTNAWCWLD FFIVDVSIVS LVANALGYSD
     LGPIKSLRTL RALRPLRALS RFEGMRVVVN ALVGAIPSIM NVLLVCLIFW LIFSIMGVNL
     FAGKYYFCFN ETSEEYFPTD VVDNKTQCLE LINQNNSEVR WKNVKINFDN VGAGYLALLQ
     VATFKGWMDI MYAAVDSREV EDQPDYEVNI YMYIYFVVFI IFGSFFTLNL FIGVIIDNFN
     QQKKKFGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPQ NKIQGMVFDF VTQQVFDISI
     MILICLNMVT MMVETDDQSD ETEIVLYWVN FIFIVIFTTE FLLKLFALRH YYFTNGWNIF
     DVVVVILSIV GMFLADLIEK YFVSPTLFRV IRLARIGRIL RLIKGAKGIR TLLFALMMSL
     PALFNIGLLL FLVMFIFSIF GMSNFGYVKH GAGIDDLYNF ETFGNSMIIL FMITTSAGWD
     GLLLPILNYP PDCDPNLENP GTSVKGDCGN PSVGIFFFVM YIIISFLIVV NMYIAIILEN
     FSVATEESAD PLSEDDFETF YEIWEKFDPT ASQFISFAKL SDFADALEHP LRVPKPNTIE
     LIAMDMPMVS GDRIHCLDIL FAFTKRVLGD SGELDMLRQQ MEERFVAANP SKVSYEPITT
     TLRRKQEDVS ARTIQNAYRA HLIRRGIIFK RVFANNKLEN GGTNQEKKES TPSTASLPSY
     DSVTKPEKEK QDDNKEEWAR KEKDKNQKDE WESKC
//
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