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Database: UniProt
Entry: I3K1K6_ORENI
LinkDB: I3K1K6_ORENI
Original site: I3K1K6_ORENI 
ID   I3K1K6_ORENI            Unreviewed;      1641 AA.
AC   I3K1K6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   30-AUG-2017, entry version 36.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A (1 of many) {ECO:0000313|Ensembl:ENSONIP00000015001};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015001, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000015001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000015001}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000015001}.
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DR   EMBL; AERX01019392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01019393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSONIT00000015014; ENSONIP00000015001; ENSONIG00000011915.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     35     53       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     74    101       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    411    429       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    441    459       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    521    549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    608    634       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    857    875       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    896    915       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    927    947       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    973    999       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1096   1122       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1181   1199       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1211   1229       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1241   1261       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1298   1326       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1401   1424       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       26    108       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      182    359       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      411    638       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      648    850       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      855   1130       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1180   1434       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       98    136       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1641 AA;  186867 MW;  B411F8F991258E87 CRC64;
     MPCSVSMCLS LALSPPLSRC PEGYTCMKAG RNPNYGYTSF DSFGWAFLAL FRLMTQDFWE
     NLYMLTLRAA GKTYMIFFVL VIFVGSFYLV NLILAVVAMA YEEQNQATME EAAQKEEEFK
     AMLEQLKKQQ EDAQTAAMAT SAGTVSEDAV EDDGGGRLSC SSSEMSKLSS KSAKERRNRK
     KKWRQKEQEK EKGDSEKFVK SESDDGSKRS RFRFPDNRLG RKSSIMNQSL LSIPGSPFLS
     RHNSKSSIFS FKGRSKDVGS ENEFADDEHS TVEECEERRG SLFSPYRRSS YTGFHGKRNS
     TVDCNGVVSL IGPGPGGRLL PEPTTEVEVK KKLSGSLMVS VDQLNTSFGR KERANSVMSV
     ITNTLVEELE ESQRKCPPCW YKFANTFLIW ECCPMWIKIK EIVNLIVMDP FVDLAITICI
     VLNTLFMAME HYPMTSDFED MLSVGNLVFT GIFAGEMLFK LVAMDPYYYF QEAWNCFDGF
     IVTLSLVELA LADVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA
     IIVFIFAVVG MQLFGKNYKD CVCKISAECE LPRWHMNDFF HSFLIVFRVL CGEWIETMWD
     CMEVAGQAMC LIVFMMVMVI GNLVVLNLFL ALLLSSFSAD NLAATDDDGE PNNLQISVMR
     IKKGIAWIKA KMRLLVASLL RKPPMEDEQK PLEDMYDKKL NCIANHTGVD INRDLDYAKN
     GNGTTSGIGS SVGKYMIDED HMSFIHNPNL TVCVPIAVGE SDFENLNTED FSSESDNENS
     KELDDTSSSE GSTIDIKPDV EEVVVVETVE EYMEPEPCWT DACVAKYKCC DVDITMGWGK
     SWWFLRKTCY LIVEHNWFET LIIFMILLSS GALAFEDVYI EQRKTVRIIL EYADRVFTYI
     FILEMLLKWV AYGFVKYFTN AWCWLDFFIV DVSIVSLVAN ALGYSDLGPI KSLRTLRALR
     PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK YYFCFNETSE
     EYFPTDVVDN KTQCLELINQ NNSEVRWKNV KINFDNVGAG YLALLQVATF KGWMDIMYAA
     VDSREVEDQP DYEVNIYMYI YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT
     EEQKKYYNAM KKLGSKKPQK PIPRPQNKIQ GMVFDFVTQQ VFDISIMILI CLNMVTMMVE
     TDDQSDETEI VLYWVNFIFI VIFTTEFLLK LFALRHYYFT NGWNIFDVVV VILSIVGMFL
     ADLIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM
     FIFSIFGMSN FGYVKHGAGI DDLYNFETFG NSMIILFMIT TSAGWDGLLL PILNYPPDCD
     PNLENPGTSV KGDCGNPSVG IFFFVMYIII SFLIVVNMYI AIILENFSVA TEESADPLSE
     DDFETFYEIW EKFDPTASQF ISFAKLSDFA DALEHPLRVP KPNTIELIAM DMPMVSGDRI
     HCLDILFAFT KRVLGDSGEL DMLRQQMEER FVAANPSKVS YEPITTTLRR KQEDVSARTI
     QNAYRAHLIR RGIIFKRVFA NNKLENGGTN QEKKESTPST ASLPSYDSVT KPEKEKQDDN
     KEEWARKEKD KNQKDEWESK C
//
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