ID I3K1W0_ORENI Unreviewed; 2728 AA.
AC I3K1W0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Neurobeachin like 1 {ECO:0000313|Ensembl:ENSONIP00000015105.2};
GN Name=NBEAL1 {ECO:0000313|Ensembl:ENSONIP00000015105.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015105.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015105.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019207272.1; XM_019351727.1.
DR Ensembl; ENSONIT00000015118.2; ENSONIP00000015105.2; ENSONIG00000012000.2.
DR eggNOG; KOG1787; Eukaryota.
DR GeneTree; ENSGT00940000155041; -.
DR TreeFam; TF323165; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF115; NEUROBEACHIN-LIKE PROTEIN 1; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1917..2014
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2025..2317
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2521..2562
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 731..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2728 AA; 307999 MW; EFE944E48A7D8150 CRC64;
MASNERLYEV WMLYCTKRDP DYLKLWLEIF ISSYERCLDV DFEKTPSRPE EVPPVLTLLP
DNILQVLRHQ LLQCVQKASD GLEPEQQNLA LLLLKFLIII CRNLSNVEEI GTCSYINHII
TMTTLYIQQL KSKTKEKEMV DQSQAEEFVR HALAFCESLY DPYHNWRHRT CGEQQMGTVE
RSRQKYKAAP LTVEFVPFFY QCFQESEHLK ESLKCCLLHL FGAIVAGDQR NALLAISPAT
MEVLMRVLAD CSMGSCSSDE GEDWDSEAPD RKALLTLGCL REVVQRLLAS SSDQRQVEIA
SVLENYFKLL NSDPAAVVAA QQQQQQAKGR VPTLGRHWES RFVALQVNML DTIRDMFLCS
DRPVLQAIFL NSNCFEHLTR LLQNSKVFQG RLDSLAVATI KALTTVMHKS PAAKEVFKER
IGYNHLYEVL ISLGQPSRHL LKELMNMAVE GEHTSVGLLG ISNVEPLLLL VQWLPELDSS
ELQLFTADWL RRLSCLNRQT RATCVNAAMV MRALAALERH ERLHRACAES LLGLVGSLGC
QSLSARELLE FLRLLRPPES SQAHPYVGPA LKALLAMVRK QGLESAMQYF DLSPSMAGIV
VPTVHRWPGS AFSFLAWLSL DQDQLGPSSK DKRKQLYSFF TPGGTGFEAF ISSAGVLVVA
VCTKKEYVTV MLPDYCFCDS LWHSIGVVHV PGKRPFGQSL VYIYVDGQQK LSAPLKYPTM
TEPFTSCCIG SAGQRTTTPP PSQIPDPPFS SATTPTTRSS LGGILSPHTW GGLLGGKPES
VTKLISAGTQ DSEWGSPTSL QGQLGSVMVF HEPLQQNHIK AICSAGPNCI SPFKAQESEL
GDLSAKLLLH YSPKACRNPI CLDLSPNMLH GRLTGNKVVN WDIKDMINCV GGLPVLFPIL
EQLAFVTPDQ QMNDPAGSDF ITPDVTTPAD GDWVILPSNR SSEARLEKNL VATFLLVLKH
FLQRHPINQE NLLYLHGVGT LGALLQKLPA GHVGVSVLVA VQLLIEQVTY EKNQALLQQL
HTHLLFNFNI WNKGDFPLRI GHIQYMSTVI KDNRKQFRKK YGVQFLVDTI RLYYGKNTNK
ESDLSEDDVR TIRASLCSLI KYYISKGMSQ DEMQSILGYI AAIGDEDQLC ALLELLLSLL
QSSPAKDQLF LLLFEPAAAD SCYALLLNNK HSDRLRELVF KLFERMLRCD RVYEKNKQRL
RLREAGYSGL SLLFSELHIT PTLIRCLLNQ VLHTDQVVNY KDLMALVQLT HRAGPSVRLI
VCKRVYQLLQ SQQDAAAQIS KQQCWQDTLM RLYLRGEGSL ALRSSDTVST CSLELSRTSG
GSNRLELPLE RRARAGSAGR LDRVEDDRIS ISDTRSVDSL ENGDVISLLD TPSSSASTEP
QPHVKPWVVG KSGGLMLDLS HLQAYEGGES GSQTPGSMPS TPSPLETSKP FPGNSGDRDA
TSSLTEDSFL FSDNISLGES FNNVERAEEE LCSMLLEIIL CVMWRGVEGS DDSAWLERGQ
VFSALTKLGT ANELLLPVDQ IKLSLMERML EWAVSDNREA SAATLPQHTE NAVRLLHMVQ
DFLQAEGLIN PALWTEKVLE EAVTLMDSLM VWYSSGSQWF QLSQVGLRLL LGFMAQQDPE
VCAMATAKLN GILQTKEISS QDEACYLLGK VEGILRRSIQ EQTEEMYSFL VPLLRTLLSK
VHRLLYMELH LPQLPDTNGS PSFFDDFKLY CNSPEWRVYL DKYIIPYMKQ YEIEMFSQGH
ETMALYWKEC YEAFMVSLHK RERERGESKI RFQEQFVEPF SRRGRQENLR YNSMLKQQHS
QNNATLRQWK AARRGLVCER GPWADRHQDE MHWRVSSAEN YSRMRLKLVR NYNFDAHREA
SALRDNLGVH QQRVNPESLL LEAVKQVKVS DLEDDILELP EDDPVAANNQ VEADEAGQKE
KLVLWEDCEL VTIVDVVPGR LELTTQHIYF YDSSQEKEEG VGHDFKWPLS QIREVHLRRY
NLRRSALEIF LIDQTNYFLN FKKEARNKVY SRMLLLRSLN LYETRSPQEL LKASGLTQKW
VNREISNFDY LMQLNTIAGR TYNDLAQYPV FPWILADYTS EELDLSDPRV FRDLSKPVAV
LNERNAKAVR EKYESFEDPT GTIDRFHYGT HYSNAAGVMH YMIRVEPFTS LHIQLQSGRF
DCADRQFHSI PATWQTLMDN PNDVKELIPE FFYFPEFLEN QNGFDLGRLQ ISKERVNDVV
LPKWAKSPED FIYKHRKALE SEYVSAHLHE WIDLIFGYKQ KGPAAVEALN VFYYCTYEGA
VDLDAITDEK ERKALEGMIS NFGQTPCQLL KEPHPVRLSQ EEVEKRKAQL DSCPFSMFEH
LSDLKSFFVE GISDNVPLVK VVVPKNQSHS FITQGSPDTM VTVSQNCLLG THGWLPYNKN
ISNYFTFIKD PTVSNTKTQR FLSGPFAPGV EVTAGLFVVS HDGKLLFSGG HWDNSLRVTS
LVKGKTVGQH IRHMDIVTCL STDHCGIHLI SGSRDTTCMV WQVLQQGGAP VGLHPKPIQV
LYGHTDEVVS VSISTELDMA VSGSRDGTVI IHTVRRGQYM RCLRPPCDSS LPLSILHLAV
SWEGHMLVHT CLEGKATLKD KNALHLYSVN GKHLCSEPLM EQVTDMCVSG EYVVIGSEQG
YLSIRDLYSL SLCAEPMAMR VPVCCVSVTK EQSHVLVGLE DGKLIIVAVG KPAEMRSGQI
TRKLWGSSKR LTQISSGETV YNTQQDHN
//
