ID I3K227_ORENI Unreviewed; 824 AA.
AC I3K227;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Zinc finger FYVE domain-containing protein 1 {ECO:0000313|Ensembl:ENSONIP00000015172.2};
GN Name=ZFYVE1 {ECO:0000313|Ensembl:ENSONIP00000015172.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015172.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015172.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3K227; -.
DR STRING; 8128.ENSONIP00000015172; -.
DR Ensembl; ENSONIT00000015185.2; ENSONIP00000015172.2; ENSONIG00000012057.2.
DR eggNOG; KOG1818; Eukaryota.
DR GeneTree; ENSGT00390000016097; -.
DR HOGENOM; CLU_020922_0_0_1; -.
DR InParanoid; I3K227; -.
DR TreeFam; TF323237; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19820; Bbox1_ZFYVE1_rpt2; 1.
DR CDD; cd01851; GBP; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR042427; ZFYV1.
DR InterPro; IPR047855; ZFYVE1_second_BBox1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46624; AGAP002036-PA; 1.
DR PANTHER; PTHR46624:SF3; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 13..63
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 613..668
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 106..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 824 AA; 90556 MW; CAD718651FD163B5 CRC64;
MNGYGSSSEK GVNTSLICQE SYSCGGFEEA AFECVDCKSL QCVRCELDLH SHDRLKNHER
VQLGPGHVPY CDNCKGGSGD SGTRHRSVVR CQNCKVNLCQ DCQKRTHSGG NKKKHQLTHY
PPPPKPAEGN SVQTSAQPAV CIADEIKSQK AKLLEKVSSF LLVDENEEMQ IKDEASFMKS
LSCSPDQLLK VVSIFGNTGE GKSHTLNHTF FMGREVFKTS PAQESCTVGV WAAFDPIHKL
VVIDTEGLLG NSSKQGQRTR LLLKVLAISD LIIYRTHADR LHDDLFKFLG DASDAYLKHF
TKELKATTAR CGLDVPLSTL GPAVVIFHET VHTKLLGSDK SSESVDRLLL ERFRKLSRFP
EAFSSVHYWG TQTLSPPTDF RGLQNKLEQL LDNNATRSPR TPVVIFKALQ ALSERFSGEI
AGELVAHSCF FPDEYFTCSS LCLSCGSGCK NSMNHLGEGV RHEARHRCRY SAQYDNRIYT
CKACYEGGKE VIVVPKTSAS SDSPWMGLAK YAWSGYVIEC PNCGVIYRSR QYWYGNQDPV
DTVVRTEIQH VWPGSDGFLK DNSNAAQRLL DGVNLVAQSV SELSVKPAKA VTSWLTDQIA
PAYWKPNSLI LVCHKCHTVF QDNDTKHHCR ACGEGFCDGC SSKAAPVPER GWGLAPVRVC
DVCFEQRSSY AELLEAEQEE EEGGTLARKV GEAVTNTFGV VVTAIDIPLG WATSSIKRPL
SSAAATMPAC ALNAASACHS WTLKPGWPRT TATSGWNVTI AAPVLQPDRC TRTPPAAGEK
KDGCTTPQIP AWAFTASSST AVSCQRTLCR LRALHWKLCF VERA
//
